Please use this identifier to cite or link to this item: https://doi.org/10.4269/ajtmh.15-0031
Title: Differential clinical outcome of dengue infection among patients with and without HIV infection: A matched case-control study
Authors: Pang, J 
Thein, T.-L
Lye, D.C 
Leo, Y.-S 
Keywords: efavirenz
lamivudine
lopinavir
nevirapine
ritonavir
saquinavir
stavudine
zidovudine
Article
bleeding
Chinese
clinical article
clinical feature
controlled study
dengue
disease severity
eosinophil
hematocrit
highly active antiretroviral therapy
hospitalization
human
Human immunodeficiency virus infection
Human immunodeficiency virus prevalence
outcome assessment
pulse rate
adult
case control study
complication
dengue
female
Human immunodeficiency virus infection
male
middle aged
mixed infection
pathology
virology
Dengue virus
Human immunodeficiency virus
Adult
Case-Control Studies
Coinfection
Dengue
Female
HIV Infections
Humans
Male
Middle Aged
Patient Outcome Assessment
Issue Date: 2015
Citation: Pang, J, Thein, T.-L, Lye, D.C, Leo, Y.-S (2015). Differential clinical outcome of dengue infection among patients with and without HIV infection: A matched case-control study. American Journal of Tropical Medicine and Hygiene 92 (6) : 1156-1162. ScholarBank@NUS Repository. https://doi.org/10.4269/ajtmh.15-0031
Abstract: Clinical characteristics and outcome among dengue patients with and without human immunodeficiency virus (HIV) infection remain elusive. A total of 10 dengue virus (DENV)-HIV Chinese patients were compared with 40 Chinese dengue patients without HIV, who were matched for age, gender, type of care received, methods, and year of dengue diagnosis from 2005 to 2008. Univariate and multivariate conditional logistics regression were applied. DENVHIV patients were significantly associated with the World Health Organization (WHO) 2009 severe dengue (conditional odds ratio [COR] = 5.72; 95% confidence interval [CI] = 1.01-32.64) but not with the WHO 1997 dengue hemorrhagic fever/dengue shock syndrome (COR = 0.40; 95% CI = 0.09-1.71). This is mainly due to severe plasma leakage and the lack of hemorrhagic manifestations. Hospitalization duration was longer for DENV-HIV patients (10.5 days; interquartile range [IQR] = 5.5-26.3 days) compared with dengue patients (5 days; IQR = 4-6 days). There were no significant differences in presentation of clinical warning signs and symptoms at admission and during hospitalization, except for rash (adjusted COR [ACOR] = 0.06; 95% CI = 0.03-0.92). DENV-HIV patients were associated with higher pulse rate (ACOR = 1.13; 95% CI = 1.02-1.25), eosinophils proportion (ACOR = 3.07; 95% CI = 1.12-8.41) and lower hematocrit level (ACOR = 0.79; 95% CI = 0.64-0.98) compared with dengue patients. Even though DENV-HIV patients may present similarly to dengue patients, they may be more likely to have severe dengue outcome. Hence, close monitoring of DENV-HIV patients is highly recommended as part of dengue clinical care and management.
Source Title: American Journal of Tropical Medicine and Hygiene
URI: https://scholarbank.nus.edu.sg/handle/10635/174668
ISSN: 0002-9637
DOI: 10.4269/ajtmh.15-0031
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