Please use this identifier to cite or link to this item: https://doi.org/10.3389/fnbeh.2016.00082
Title: To cheat or not to cheat: Tryptophan hydroxylase 2 SNP variants contribute to dishonest behavior
Authors: Shen Q. 
Teo M.
Winter E.
Hart E.
Chew S.H.
Ebstein R.P. 
Keywords: brain protein
serotonin
tryptophan hydroxylase 2
adult
Article
dishosnest behavior
exploratory behavior
female
gene frequency
gene function
genetic association
genetic variability
haplotype
human
human experiment
male
neurotransmission
personality
serotonin metabolism
single nucleotide polymorphism
task performance
TPH2 gene
young adult
Issue Date: 2016
Publisher: Frontiers Media S. A
Citation: Shen Q., Teo M., Winter E., Hart E., Chew S.H., Ebstein R.P. (2016). To cheat or not to cheat: Tryptophan hydroxylase 2 SNP variants contribute to dishonest behavior. Frontiers in Behavioral Neuroscience 10 (MAY) : 82. ScholarBank@NUS Repository. https://doi.org/10.3389/fnbeh.2016.00082
Abstract: Although, lying (bear false witness) is explicitly prohibited in the Decalogue and a focus of interest in philosophy and theology, more recently the behavioral and neural mechanisms of deception are gaining increasing attention from diverse fields especially economics, psychology, and neuroscience. Despite the considerable role of heredity in explaining individual differences in deceptive behavior, few studies have investigated which specific genes contribute to the heterogeneity of lying behavior across individuals. Also, little is known concerning which specific neurotransmitter pathways underlie deception. Toward addressing these two key questions, we implemented a neurogenetic strategy and modeled deception by an incentivized die-under-cup task in a laboratory setting. The results of this exploratory study provide provisional evidence that SNP variants across the tryptophan hydroxylase 2 (TPH2) gene, that encodes the rate-limiting enzyme in the biosynthesis of brain serotonin, contribute to individual differences in deceptive behavior. © 2016 Shen, Teo, Winter, Hart, Chew and Ebstein.
Source Title: Frontiers in Behavioral Neuroscience
URI: https://scholarbank.nus.edu.sg/handle/10635/174257
ISSN: 16625153
DOI: 10.3389/fnbeh.2016.00082
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3389_fnbeh_2016_00082.pdf959.3 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

2
checked on Oct 14, 2021

Page view(s)

81
checked on Oct 14, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.