Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-018-06227-9
Title: Plasmodium co-infection protects against chikungunya virus-induced pathologies
Authors: Teo, T.-H
Lum, F.-M
Ghaffar, K
Chan, Y.-H
Amrun, S.N
Tan, J.J.L
Lee, C.Y.P
Chua, T.-K
Carissimo, G
Lee, W.W.L
Claser, C
Rajarethinam, R
Rénia, L 
Ng, L.F.P 
Keywords: chemokine receptor CXCR3
gamma interferon
neutralizing antibody
gamma interferon
antibody
apoptosis
cell component
chikungunya
induced response
infectious disease
infiltration
pathogen
pathology
virus
animal experiment
animal model
antibody production
apoptosis
arthritis
Article
B lymphocyte
CD4+ T lymphocyte
cell maturation
cell migration
Chikungunya virus
concurrent infection
controlled study
lymphocytic infiltration
mixed infection
mouse
nonhuman
Plasmodium
spleen
viral clearance
viremia
virus load
animal
C57BL mouse
chikungunya
Chikungunya virus
female
genetics
human
immunology
knockout mouse
malaria
male
metabolism
mixed infection
parasitology
physiology
Plasmodium
virology
Chikungunya virus
Mus
Animals
Apoptosis
Arthritis
CD4-Positive T-Lymphocytes
Chikungunya Fever
Chikungunya virus
Coinfection
Female
Humans
Interferon-gamma
Malaria
Male
Mice, Inbred C57BL
Mice, Knockout
Plasmodium
Viral Load
Viremia
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Teo, T.-H, Lum, F.-M, Ghaffar, K, Chan, Y.-H, Amrun, S.N, Tan, J.J.L, Lee, C.Y.P, Chua, T.-K, Carissimo, G, Lee, W.W.L, Claser, C, Rajarethinam, R, Rénia, L, Ng, L.F.P (2018). Plasmodium co-infection protects against chikungunya virus-induced pathologies. Nature Communications 9 (1) : 3905. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-06227-9
Abstract: Co-infection with Plasmodium and chikungunya virus (CHIKV) has been reported in humans, but the impact of co-infection on pathogenesis remains unclear. Here, we show that prior exposure to Plasmodium suppresses CHIKV-associated pathologies in mice. Mechanistically, Plasmodium infection induces IFN?, which reduces viraemia of a subsequent CHIKV infection and suppresses tissue viral load and joint inflammation. Conversely, concomitant infection with both pathogens limits the peak of joint inflammation with no effect on CHIKV viraemia. Reduced peak joint inflammation is regulated by elevated apoptosis of CD4+ T-cells in the lymph nodes and disrupted CXCR3-mediated CD4+ T-cell migration that abolishes their infiltration into the joints. Virus clearance from tissues is delayed in both infection scenarios, and is associated with a disruption of B cell affinity-maturation in the spleen that reduces CHIKV-neutralizing antibody production. © 2018, The Author(s).
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/174206
ISSN: 2041-1723
DOI: 10.1038/s41467-018-06227-9
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