Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-018-06227-9
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dc.titlePlasmodium co-infection protects against chikungunya virus-induced pathologies
dc.contributor.authorTeo, T.-H
dc.contributor.authorLum, F.-M
dc.contributor.authorGhaffar, K
dc.contributor.authorChan, Y.-H
dc.contributor.authorAmrun, S.N
dc.contributor.authorTan, J.J.L
dc.contributor.authorLee, C.Y.P
dc.contributor.authorChua, T.-K
dc.contributor.authorCarissimo, G
dc.contributor.authorLee, W.W.L
dc.contributor.authorClaser, C
dc.contributor.authorRajarethinam, R
dc.contributor.authorRénia, L
dc.contributor.authorNg, L.F.P
dc.date.accessioned2020-09-04T01:46:07Z
dc.date.available2020-09-04T01:46:07Z
dc.date.issued2018
dc.identifier.citationTeo, T.-H, Lum, F.-M, Ghaffar, K, Chan, Y.-H, Amrun, S.N, Tan, J.J.L, Lee, C.Y.P, Chua, T.-K, Carissimo, G, Lee, W.W.L, Claser, C, Rajarethinam, R, Rénia, L, Ng, L.F.P (2018). Plasmodium co-infection protects against chikungunya virus-induced pathologies. Nature Communications 9 (1) : 3905. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-06227-9
dc.identifier.issn2041-1723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/174206
dc.description.abstractCo-infection with Plasmodium and chikungunya virus (CHIKV) has been reported in humans, but the impact of co-infection on pathogenesis remains unclear. Here, we show that prior exposure to Plasmodium suppresses CHIKV-associated pathologies in mice. Mechanistically, Plasmodium infection induces IFN?, which reduces viraemia of a subsequent CHIKV infection and suppresses tissue viral load and joint inflammation. Conversely, concomitant infection with both pathogens limits the peak of joint inflammation with no effect on CHIKV viraemia. Reduced peak joint inflammation is regulated by elevated apoptosis of CD4+ T-cells in the lymph nodes and disrupted CXCR3-mediated CD4+ T-cell migration that abolishes their infiltration into the joints. Virus clearance from tissues is delayed in both infection scenarios, and is associated with a disruption of B cell affinity-maturation in the spleen that reduces CHIKV-neutralizing antibody production. © 2018, The Author(s).
dc.publisherNature Publishing Group
dc.sourceUnpaywall 20200831
dc.subjectchemokine receptor CXCR3
dc.subjectgamma interferon
dc.subjectneutralizing antibody
dc.subjectgamma interferon
dc.subjectantibody
dc.subjectapoptosis
dc.subjectcell component
dc.subjectchikungunya
dc.subjectinduced response
dc.subjectinfectious disease
dc.subjectinfiltration
dc.subjectpathogen
dc.subjectpathology
dc.subjectvirus
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantibody production
dc.subjectapoptosis
dc.subjectarthritis
dc.subjectArticle
dc.subjectB lymphocyte
dc.subjectCD4+ T lymphocyte
dc.subjectcell maturation
dc.subjectcell migration
dc.subjectChikungunya virus
dc.subjectconcurrent infection
dc.subjectcontrolled study
dc.subjectlymphocytic infiltration
dc.subjectmixed infection
dc.subjectmouse
dc.subjectnonhuman
dc.subjectPlasmodium
dc.subjectspleen
dc.subjectviral clearance
dc.subjectviremia
dc.subjectvirus load
dc.subjectanimal
dc.subjectC57BL mouse
dc.subjectchikungunya
dc.subjectChikungunya virus
dc.subjectfemale
dc.subjectgenetics
dc.subjecthuman
dc.subjectimmunology
dc.subjectknockout mouse
dc.subjectmalaria
dc.subjectmale
dc.subjectmetabolism
dc.subjectmixed infection
dc.subjectparasitology
dc.subjectphysiology
dc.subjectPlasmodium
dc.subjectvirology
dc.subjectChikungunya virus
dc.subjectMus
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectArthritis
dc.subjectCD4-Positive T-Lymphocytes
dc.subjectChikungunya Fever
dc.subjectChikungunya virus
dc.subjectCoinfection
dc.subjectFemale
dc.subjectHumans
dc.subjectInterferon-gamma
dc.subjectMalaria
dc.subjectMale
dc.subjectMice, Inbred C57BL
dc.subjectMice, Knockout
dc.subjectPlasmodium
dc.subjectViral Load
dc.subjectViremia
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY AND IMMUNOLOGY
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.description.doi10.1038/s41467-018-06227-9
dc.description.sourcetitleNature Communications
dc.description.volume9
dc.description.issue1
dc.description.page3905
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