Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41467-018-06227-9
DC Field | Value | |
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dc.title | Plasmodium co-infection protects against chikungunya virus-induced pathologies | |
dc.contributor.author | Teo, T.-H | |
dc.contributor.author | Lum, F.-M | |
dc.contributor.author | Ghaffar, K | |
dc.contributor.author | Chan, Y.-H | |
dc.contributor.author | Amrun, S.N | |
dc.contributor.author | Tan, J.J.L | |
dc.contributor.author | Lee, C.Y.P | |
dc.contributor.author | Chua, T.-K | |
dc.contributor.author | Carissimo, G | |
dc.contributor.author | Lee, W.W.L | |
dc.contributor.author | Claser, C | |
dc.contributor.author | Rajarethinam, R | |
dc.contributor.author | Rénia, L | |
dc.contributor.author | Ng, L.F.P | |
dc.date.accessioned | 2020-09-04T01:46:07Z | |
dc.date.available | 2020-09-04T01:46:07Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Teo, T.-H, Lum, F.-M, Ghaffar, K, Chan, Y.-H, Amrun, S.N, Tan, J.J.L, Lee, C.Y.P, Chua, T.-K, Carissimo, G, Lee, W.W.L, Claser, C, Rajarethinam, R, Rénia, L, Ng, L.F.P (2018). Plasmodium co-infection protects against chikungunya virus-induced pathologies. Nature Communications 9 (1) : 3905. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-06227-9 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/174206 | |
dc.description.abstract | Co-infection with Plasmodium and chikungunya virus (CHIKV) has been reported in humans, but the impact of co-infection on pathogenesis remains unclear. Here, we show that prior exposure to Plasmodium suppresses CHIKV-associated pathologies in mice. Mechanistically, Plasmodium infection induces IFN?, which reduces viraemia of a subsequent CHIKV infection and suppresses tissue viral load and joint inflammation. Conversely, concomitant infection with both pathogens limits the peak of joint inflammation with no effect on CHIKV viraemia. Reduced peak joint inflammation is regulated by elevated apoptosis of CD4+ T-cells in the lymph nodes and disrupted CXCR3-mediated CD4+ T-cell migration that abolishes their infiltration into the joints. Virus clearance from tissues is delayed in both infection scenarios, and is associated with a disruption of B cell affinity-maturation in the spleen that reduces CHIKV-neutralizing antibody production. © 2018, The Author(s). | |
dc.publisher | Nature Publishing Group | |
dc.source | Unpaywall 20200831 | |
dc.subject | chemokine receptor CXCR3 | |
dc.subject | gamma interferon | |
dc.subject | neutralizing antibody | |
dc.subject | gamma interferon | |
dc.subject | antibody | |
dc.subject | apoptosis | |
dc.subject | cell component | |
dc.subject | chikungunya | |
dc.subject | induced response | |
dc.subject | infectious disease | |
dc.subject | infiltration | |
dc.subject | pathogen | |
dc.subject | pathology | |
dc.subject | virus | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | antibody production | |
dc.subject | apoptosis | |
dc.subject | arthritis | |
dc.subject | Article | |
dc.subject | B lymphocyte | |
dc.subject | CD4+ T lymphocyte | |
dc.subject | cell maturation | |
dc.subject | cell migration | |
dc.subject | Chikungunya virus | |
dc.subject | concurrent infection | |
dc.subject | controlled study | |
dc.subject | lymphocytic infiltration | |
dc.subject | mixed infection | |
dc.subject | mouse | |
dc.subject | nonhuman | |
dc.subject | Plasmodium | |
dc.subject | spleen | |
dc.subject | viral clearance | |
dc.subject | viremia | |
dc.subject | virus load | |
dc.subject | animal | |
dc.subject | C57BL mouse | |
dc.subject | chikungunya | |
dc.subject | Chikungunya virus | |
dc.subject | female | |
dc.subject | genetics | |
dc.subject | human | |
dc.subject | immunology | |
dc.subject | knockout mouse | |
dc.subject | malaria | |
dc.subject | male | |
dc.subject | metabolism | |
dc.subject | mixed infection | |
dc.subject | parasitology | |
dc.subject | physiology | |
dc.subject | Plasmodium | |
dc.subject | virology | |
dc.subject | Chikungunya virus | |
dc.subject | Mus | |
dc.subject | Animals | |
dc.subject | Apoptosis | |
dc.subject | Arthritis | |
dc.subject | CD4-Positive T-Lymphocytes | |
dc.subject | Chikungunya Fever | |
dc.subject | Chikungunya virus | |
dc.subject | Coinfection | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Interferon-gamma | |
dc.subject | Malaria | |
dc.subject | Male | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mice, Knockout | |
dc.subject | Plasmodium | |
dc.subject | Viral Load | |
dc.subject | Viremia | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.contributor.department | DEPT OF BIOCHEMISTRY | |
dc.description.doi | 10.1038/s41467-018-06227-9 | |
dc.description.sourcetitle | Nature Communications | |
dc.description.volume | 9 | |
dc.description.issue | 1 | |
dc.description.page | 3905 | |
Appears in Collections: | Elements Staff Publications |
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