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Title: Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine
Authors: Skibinski, D.A.G
Jones, L.A
Zhu, Y.O
Xue, L.W
Au, B
Lee, B
Naim, A.N.M
Lee, A
Kaliaperumal, N
Low, J.G.H
Lee, L.S 
Poidinger, M 
Saudan, P
Bachmann, M
Ooi, E.E 
Hanson, B.J 
Novotny-Diermayr, V
Matter, A
Fairhurst, A.-M
Hibberd, M.L 
Connolly, J.E 
Keywords: cytokine
influenza vaccine
antibody production
CD4+ T lymphocyte
CD8+ T lymphocyte
cell proliferation
cellular immunity
clinical trial
cohort analysis
controlled study
lymphocyte activation
middle aged
multicenter study
phase 1 clinical trial
randomized controlled trial
young adult
Antibody Formation
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Proliferation
Cohort Studies
Immunity, Cellular
Influenza Vaccines
Influenza, Human
Lymphocyte Activation
Middle Aged
Young Adult
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Skibinski, D.A.G, Jones, L.A, Zhu, Y.O, Xue, L.W, Au, B, Lee, B, Naim, A.N.M, Lee, A, Kaliaperumal, N, Low, J.G.H, Lee, L.S, Poidinger, M, Saudan, P, Bachmann, M, Ooi, E.E, Hanson, B.J, Novotny-Diermayr, V, Matter, A, Fairhurst, A.-M, Hibberd, M.L, Connolly, J.E (2018). Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine. Scientific Reports 8 (1) : 18007. ScholarBank@NUS Repository.
Abstract: Cell mediated immunity plays a vital role in defense against influenza infection in humans. Less is known about the role of vaccine-induced cell mediated immunity and the cytokine responses elicited. We measured CD4+ and CD8+ T-cell reactivity in human subjects following vaccination with licensed trivalent influenza vaccine and a novel virus-like particle based vaccine. We detected influenza-specific CD4+ T-cell responses following vaccination with the licensed trivalent influenza vaccine and found that these correlated with antibody measurements. Administration of the novel virus-like particle based vaccine elicited influenza-specific CD4+ and CD8+ T-cell responses and the induction of the cytokines IFN-?, IL-17A, IL17F, IL-5, IL-13, IL-9, IL-10 and IL-21. Pre-existing cytokine responses influenced the profile of the cytokine response elicited by vaccination. In a subset of individuals the VLP vaccine changed pre-vaccination production of type 2 cytokines such as IL-5 and IL-13 to a post-vaccination type 1 cytokine signature characterized by IFN-?. A transcriptional signature to vaccination was found to correlate with antibody titer, IFN-? production by T-cells and expression of a putative RNA helicase, DDX17, on the surface of immune cells. © 2018, The Author(s).
Source Title: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-018-36703-7
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