Please use this identifier to cite or link to this item: https://doi.org/10.1126/sciadv.aba5136
Title: Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression
Authors: Han, Jian 
An, Omer 
Hong, HuiQi 
Chan, Tim Hon Man
Song, Yangyang 
Shen, Haoqing
Tang, Sze Jing 
Lin, Jaymie Siqi 
Ng, Vanessa Hui En 
Tay, Daryl Jin Tai 
Molias, Fernando Bellido 
Pitcheshwar, Priyankaa
Tan, Hui Qing 
Yang, Henry
Chen, Leilei 
Issue Date: 17-Jun-2020
Publisher: American Association for the Advancement of Science (AAAS)
Citation: Han, Jian, An, Omer, Hong, HuiQi, Chan, Tim Hon Man, Song, Yangyang, Shen, Haoqing, Tang, Sze Jing, Lin, Jaymie Siqi, Ng, Vanessa Hui En, Tay, Daryl Jin Tai, Molias, Fernando Bellido, Pitcheshwar, Priyankaa, Tan, Hui Qing, Yang, Henry, Chen, Leilei (2020-06-17). Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression. Science Advances 6 (25) : eaba5136-eaba5136. ScholarBank@NUS Repository. https://doi.org/10.1126/sciadv.aba5136
Abstract: RNA editing introduces nucleotide changes in RNA sequences. Recent studies have reported that aberrant A-to-I RNA editing profiles are implicated in cancers. Albeit changes in expression and activity of ADAR genes are thought to have been responsible for the dysregulated RNA editome in diseases, they are not always correlated, indicating the involvement of secondary regulators. Here, we uncover DAP3 as a potent repressor of editing and a strong oncogene in cancer. DAP3 mainly interacts with the deaminase domain of ADAR2 and represses editing via disrupting association of ADAR2 with its target transcripts. PDZD7, an exemplary DAP3-repressed editing target, undergoes a protein recoding editing at stop codon [Stop →Trp (W)]. Because of editing suppression by DAP3, the unedited PDZD7WT, which is more tumorigenic than edited PDZD7Stop518W, is accumulated in tumors. In sum, cancer cells may acquire malignant properties for their survival advantage through suppressing RNA editome by DAP3.
Source Title: Science Advances
URI: https://scholarbank.nus.edu.sg/handle/10635/170640
ISSN: 2375-2548
DOI: 10.1126/sciadv.aba5136
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