Please use this identifier to cite or link to this item: https://doi.org/10.1126/sciadv.aba5136
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dc.titleSuppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression
dc.contributor.authorHan, Jian
dc.contributor.authorAn, Omer
dc.contributor.authorHong, HuiQi
dc.contributor.authorChan, Tim Hon Man
dc.contributor.authorSong, Yangyang
dc.contributor.authorShen, Haoqing
dc.contributor.authorTang, Sze Jing
dc.contributor.authorLin, Jaymie Siqi
dc.contributor.authorNg, Vanessa Hui En
dc.contributor.authorTay, Daryl Jin Tai
dc.contributor.authorMolias, Fernando Bellido
dc.contributor.authorPitcheshwar, Priyankaa
dc.contributor.authorTan, Hui Qing
dc.contributor.authorYang, Henry
dc.contributor.authorChen, Leilei
dc.date.accessioned2020-06-22T07:21:59Z
dc.date.available2020-06-22T07:21:59Z
dc.date.issued2020-06-17
dc.identifier.citationHan, Jian, An, Omer, Hong, HuiQi, Chan, Tim Hon Man, Song, Yangyang, Shen, Haoqing, Tang, Sze Jing, Lin, Jaymie Siqi, Ng, Vanessa Hui En, Tay, Daryl Jin Tai, Molias, Fernando Bellido, Pitcheshwar, Priyankaa, Tan, Hui Qing, Yang, Henry, Chen, Leilei (2020-06-17). Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression. Science Advances 6 (25) : eaba5136-eaba5136. ScholarBank@NUS Repository. https://doi.org/10.1126/sciadv.aba5136
dc.identifier.issn2375-2548
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/170640
dc.description.abstract<jats:p>RNA editing introduces nucleotide changes in RNA sequences. Recent studies have reported that aberrant A-to-I RNA editing profiles are implicated in cancers. Albeit changes in expression and activity of <jats:italic>ADAR</jats:italic> genes are thought to have been responsible for the dysregulated RNA editome in diseases, they are not always correlated, indicating the involvement of secondary regulators. Here, we uncover DAP3 as a potent repressor of editing and a strong oncogene in cancer. DAP3 mainly interacts with the deaminase domain of ADAR2 and represses editing via disrupting association of ADAR2 with its target transcripts. <jats:italic>PDZD7</jats:italic>, an exemplary DAP3-repressed editing target, undergoes a protein recoding editing at stop codon [Stop →Trp (W)]. Because of editing suppression by DAP3, the unedited PDZD7<jats:sup>WT</jats:sup>, which is more tumorigenic than edited PDZD7<jats:sup>Stop518W</jats:sup>, is accumulated in tumors. In sum, cancer cells may acquire malignant properties for their survival advantage through suppressing RNA editome by DAP3.</jats:p>
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.sourceElements
dc.typeArticle
dc.date.updated2020-06-19T12:49:51Z
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentDEPT OF ANATOMY
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.description.doi10.1126/sciadv.aba5136
dc.description.sourcetitleScience Advances
dc.description.volume6
dc.description.issue25
dc.description.pageeaba5136-eaba5136
dc.published.statePublished
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