Please use this identifier to cite or link to this item: https://doi.org/10.1194/jlr.S087163
Title: MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines
Authors: Burla, Bo
Arita, Makoto
Arita, Masanori
Bendt, Anne K 
Cazenave-Gassiot, Amaury 
Dennis, Edward A
Ekroos, Kim
Han, Xianlin
Ikeda, Kazutaka
Liebisch, Gerhard
Lin, Michelle K
Loh, Tze Ping
Meikle, Peter J
Oresic, Matej
Quehenberger, Oswald
Shevchenko, Andrej
Torta, Federico 
Wakelam, Michael JO
Wheelock, Craig E
Wenk, Markus R 
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
clinical trials
diagnostic tools
lipids
mass spectrometry
absolute concentrations
clinical research
data sharing
National Institute of Standards and Technology Standard Reference Material 1950
quality control
STANDARD REFERENCE MATERIAL
LC-MS/MS METHOD
MASS-SPECTROMETRY
HIGH-THROUGHPUT
SHOTGUN LIPIDOMICS
QUANTITATIVE-ANALYSIS
GAS-CHROMATOGRAPHY
QUALITY ASSESSMENT
SERUM
METABOLITES
Issue Date: 1-Oct-2018
Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Citation: Burla, Bo, Arita, Makoto, Arita, Masanori, Bendt, Anne K, Cazenave-Gassiot, Amaury, Dennis, Edward A, Ekroos, Kim, Han, Xianlin, Ikeda, Kazutaka, Liebisch, Gerhard, Lin, Michelle K, Loh, Tze Ping, Meikle, Peter J, Oresic, Matej, Quehenberger, Oswald, Shevchenko, Andrej, Torta, Federico, Wakelam, Michael JO, Wheelock, Craig E, Wenk, Markus R (2018-10-01). MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines. JOURNAL OF LIPID RESEARCH 59 (10) : 2001-2017. ScholarBank@NUS Repository. https://doi.org/10.1194/jlr.S087163
Abstract: Copyright © 2018 Burla et al. Published by The American Society for Biochemistry and Molecular Biology, Inc. Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) offers insights into individual metabolism and physiology in health and disease. Disturbances in the plasma lipidome also occur in conditions that are not directly linked to lipid metabolism; therefore, plasma lipidomics based on MS is an emerging tool in an array of clinical diagnostics and disease management. However, challenges exist in the translation of such lipidomic data to clinical applications. These relate to the reproducibility, accuracy, and precision of lipid quantitation, study design, sample handling, and data sharing. This position paper emerged from a workshop that initiated a community-led process to elaborate and define a set of generally accepted guidelines for quantitative MS-based lipidomics of blood plasma or serum, with harmonization of data acquired on different instrumentation platforms across independent laboratories as an ultimate goal. We hope that other fields may benefit from and follow such a precedent.
Source Title: JOURNAL OF LIPID RESEARCH
URI: https://scholarbank.nus.edu.sg/handle/10635/170370
ISSN: 00222275
15397262
DOI: 10.1194/jlr.S087163
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