Please use this identifier to cite or link to this item: https://doi.org/10.1194/jlr.S087163
DC FieldValue
dc.titleMS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines
dc.contributor.authorBurla, Bo
dc.contributor.authorArita, Makoto
dc.contributor.authorArita, Masanori
dc.contributor.authorBendt, Anne K
dc.contributor.authorCazenave-Gassiot, Amaury
dc.contributor.authorDennis, Edward A
dc.contributor.authorEkroos, Kim
dc.contributor.authorHan, Xianlin
dc.contributor.authorIkeda, Kazutaka
dc.contributor.authorLiebisch, Gerhard
dc.contributor.authorLin, Michelle K
dc.contributor.authorLoh, Tze Ping
dc.contributor.authorMeikle, Peter J
dc.contributor.authorOresic, Matej
dc.contributor.authorQuehenberger, Oswald
dc.contributor.authorShevchenko, Andrej
dc.contributor.authorTorta, Federico
dc.contributor.authorWakelam, Michael JO
dc.contributor.authorWheelock, Craig E
dc.contributor.authorWenk, Markus R
dc.date.accessioned2020-06-18T06:11:44Z
dc.date.available2020-06-18T06:11:44Z
dc.date.issued2018-10-01
dc.identifier.citationBurla, Bo, Arita, Makoto, Arita, Masanori, Bendt, Anne K, Cazenave-Gassiot, Amaury, Dennis, Edward A, Ekroos, Kim, Han, Xianlin, Ikeda, Kazutaka, Liebisch, Gerhard, Lin, Michelle K, Loh, Tze Ping, Meikle, Peter J, Oresic, Matej, Quehenberger, Oswald, Shevchenko, Andrej, Torta, Federico, Wakelam, Michael JO, Wheelock, Craig E, Wenk, Markus R (2018-10-01). MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines. JOURNAL OF LIPID RESEARCH 59 (10) : 2001-2017. ScholarBank@NUS Repository. https://doi.org/10.1194/jlr.S087163
dc.identifier.issn00222275
dc.identifier.issn15397262
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/170370
dc.description.abstractCopyright © 2018 Burla et al. Published by The American Society for Biochemistry and Molecular Biology, Inc. Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) offers insights into individual metabolism and physiology in health and disease. Disturbances in the plasma lipidome also occur in conditions that are not directly linked to lipid metabolism; therefore, plasma lipidomics based on MS is an emerging tool in an array of clinical diagnostics and disease management. However, challenges exist in the translation of such lipidomic data to clinical applications. These relate to the reproducibility, accuracy, and precision of lipid quantitation, study design, sample handling, and data sharing. This position paper emerged from a workshop that initiated a community-led process to elaborate and define a set of generally accepted guidelines for quantitative MS-based lipidomics of blood plasma or serum, with harmonization of data acquired on different instrumentation platforms across independent laboratories as an ultimate goal. We hope that other fields may benefit from and follow such a precedent.
dc.language.isoen
dc.publisherAMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectBiochemistry & Molecular Biology
dc.subjectclinical trials
dc.subjectdiagnostic tools
dc.subjectlipids
dc.subjectmass spectrometry
dc.subjectabsolute concentrations
dc.subjectclinical research
dc.subjectdata sharing
dc.subjectNational Institute of Standards and Technology Standard Reference Material 1950
dc.subjectquality control
dc.subjectSTANDARD REFERENCE MATERIAL
dc.subjectLC-MS/MS METHOD
dc.subjectMASS-SPECTROMETRY
dc.subjectHIGH-THROUGHPUT
dc.subjectSHOTGUN LIPIDOMICS
dc.subjectQUANTITATIVE-ANALYSIS
dc.subjectGAS-CHROMATOGRAPHY
dc.subjectQUALITY ASSESSMENT
dc.subjectSERUM
dc.subjectMETABOLITES
dc.typeArticle
dc.date.updated2020-06-17T05:05:03Z
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.1194/jlr.S087163
dc.description.sourcetitleJOURNAL OF LIPID RESEARCH
dc.description.volume59
dc.description.issue10
dc.description.page2001-2017
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
67. MS-based lipidomics of human blood plasma.pdfPublished version1.45 MBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

70
checked on Sep 26, 2020

Page view(s)

32
checked on Sep 24, 2020

Download(s)

1
checked on Sep 24, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.