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https://doi.org/10.1039/c5sc00826c
Title: | Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics | Authors: | Zhang, Chong-Jing Hu, Qinglian Feng, Guangxue Zhang, Ruoyu Yuan, Youyong Lu, Xianmao Liu, Bin |
Keywords: | Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry LIGHT-UP PROBE CANCER-CHEMOTHERAPY DRUG-DELIVERY IN-VITRO CELLS APOPTOSIS BIOPROBE STRATEGY ABLATION UPDATE |
Issue Date: | 1-Jan-2015 | Publisher: | ROYAL SOC CHEMISTRY | Citation: | Zhang, Chong-Jing, Hu, Qinglian, Feng, Guangxue, Zhang, Ruoyu, Yuan, Youyong, Lu, Xianmao, Liu, Bin (2015-01-01). Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics. CHEMICAL SCIENCE 6 (8) : 4580-4586. ScholarBank@NUS Repository. https://doi.org/10.1039/c5sc00826c | Abstract: | © The Royal Society of Chemistry. Subcellular targeted cancer therapy and in situ monitoring of therapeutic effect are highly desirable for clinical applications. Herein, we report a series of probes by conjugating zero (TPECM-2Br), one (TPECM-1TPP) and two (TPECM-2TPP) triphenylphosphine (TPP) ligands to a fluorogen with aggregation-induced emission (AIE) characteristics. The probes are almost non-emissive as molecularly dissolved species, but they can light up in cell cytoplasm or mitochondria. TPECM-2TPP is found to be able to target mitochondria, depolarize mitochondria membrane potential and selectively exert potent chemo-cytotoxicity on cancer cells. Furthermore, it can efficiently generate singlet oxygen with strong photo-toxicity upon light illumination, which further enhances its anti-cancer effect. On the other hand, TPECM-1TPP can also target mitochondria and generate singlet oxygen to trigger cancer cell apoptosis, but it shows low cytotoxicity in dark. Meanwhile, TPECM-1TPP can report the cellular oxidative stress by visualizing the morphological changes of mitochondria. However, TPECM-2Br does not target mitochondria and shows no obvious anticancer effect either in dark or under light illumination. This study thus highlights the importance of molecular probe design, which yields a new generation of subcellular targeted molecular theranostic agents with multi-function, such as cancer cell imaging, chemotherapy, photodynamic therapy, and in situ monitoring of the therapeutic effect in one go. | Source Title: | CHEMICAL SCIENCE | URI: | https://scholarbank.nus.edu.sg/handle/10635/169762 | ISSN: | 20416520 20416539 |
DOI: | 10.1039/c5sc00826c |
Appears in Collections: | Staff Publications Elements |
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