Please use this identifier to cite or link to this item: https://doi.org/10.1039/c5sc00826c
Title: Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics
Authors: Zhang, Chong-Jing 
Hu, Qinglian 
Feng, Guangxue 
Zhang, Ruoyu 
Yuan, Youyong 
Lu, Xianmao 
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
LIGHT-UP PROBE
CANCER-CHEMOTHERAPY
DRUG-DELIVERY
IN-VITRO
CELLS
APOPTOSIS
BIOPROBE
STRATEGY
ABLATION
UPDATE
Issue Date: 1-Jan-2015
Publisher: ROYAL SOC CHEMISTRY
Citation: Zhang, Chong-Jing, Hu, Qinglian, Feng, Guangxue, Zhang, Ruoyu, Yuan, Youyong, Lu, Xianmao, Liu, Bin (2015-01-01). Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics. CHEMICAL SCIENCE 6 (8) : 4580-4586. ScholarBank@NUS Repository. https://doi.org/10.1039/c5sc00826c
Abstract: © The Royal Society of Chemistry. Subcellular targeted cancer therapy and in situ monitoring of therapeutic effect are highly desirable for clinical applications. Herein, we report a series of probes by conjugating zero (TPECM-2Br), one (TPECM-1TPP) and two (TPECM-2TPP) triphenylphosphine (TPP) ligands to a fluorogen with aggregation-induced emission (AIE) characteristics. The probes are almost non-emissive as molecularly dissolved species, but they can light up in cell cytoplasm or mitochondria. TPECM-2TPP is found to be able to target mitochondria, depolarize mitochondria membrane potential and selectively exert potent chemo-cytotoxicity on cancer cells. Furthermore, it can efficiently generate singlet oxygen with strong photo-toxicity upon light illumination, which further enhances its anti-cancer effect. On the other hand, TPECM-1TPP can also target mitochondria and generate singlet oxygen to trigger cancer cell apoptosis, but it shows low cytotoxicity in dark. Meanwhile, TPECM-1TPP can report the cellular oxidative stress by visualizing the morphological changes of mitochondria. However, TPECM-2Br does not target mitochondria and shows no obvious anticancer effect either in dark or under light illumination. This study thus highlights the importance of molecular probe design, which yields a new generation of subcellular targeted molecular theranostic agents with multi-function, such as cancer cell imaging, chemotherapy, photodynamic therapy, and in situ monitoring of the therapeutic effect in one go.
Source Title: CHEMICAL SCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/169762
ISSN: 20416520
20416539
DOI: 10.1039/c5sc00826c
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