Please use this identifier to cite or link to this item: https://doi.org/10.1039/c5sc00826c
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dc.titleImage-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics
dc.contributor.authorZhang, Chong-Jing
dc.contributor.authorHu, Qinglian
dc.contributor.authorFeng, Guangxue
dc.contributor.authorZhang, Ruoyu
dc.contributor.authorYuan, Youyong
dc.contributor.authorLu, Xianmao
dc.contributor.authorLiu, Bin
dc.date.accessioned2020-06-15T03:08:21Z
dc.date.available2020-06-15T03:08:21Z
dc.date.issued2015-01-01
dc.identifier.citationZhang, Chong-Jing, Hu, Qinglian, Feng, Guangxue, Zhang, Ruoyu, Yuan, Youyong, Lu, Xianmao, Liu, Bin (2015-01-01). Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics. CHEMICAL SCIENCE 6 (8) : 4580-4586. ScholarBank@NUS Repository. https://doi.org/10.1039/c5sc00826c
dc.identifier.issn20416520
dc.identifier.issn20416539
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169762
dc.description.abstract© The Royal Society of Chemistry. Subcellular targeted cancer therapy and in situ monitoring of therapeutic effect are highly desirable for clinical applications. Herein, we report a series of probes by conjugating zero (TPECM-2Br), one (TPECM-1TPP) and two (TPECM-2TPP) triphenylphosphine (TPP) ligands to a fluorogen with aggregation-induced emission (AIE) characteristics. The probes are almost non-emissive as molecularly dissolved species, but they can light up in cell cytoplasm or mitochondria. TPECM-2TPP is found to be able to target mitochondria, depolarize mitochondria membrane potential and selectively exert potent chemo-cytotoxicity on cancer cells. Furthermore, it can efficiently generate singlet oxygen with strong photo-toxicity upon light illumination, which further enhances its anti-cancer effect. On the other hand, TPECM-1TPP can also target mitochondria and generate singlet oxygen to trigger cancer cell apoptosis, but it shows low cytotoxicity in dark. Meanwhile, TPECM-1TPP can report the cellular oxidative stress by visualizing the morphological changes of mitochondria. However, TPECM-2Br does not target mitochondria and shows no obvious anticancer effect either in dark or under light illumination. This study thus highlights the importance of molecular probe design, which yields a new generation of subcellular targeted molecular theranostic agents with multi-function, such as cancer cell imaging, chemotherapy, photodynamic therapy, and in situ monitoring of the therapeutic effect in one go.
dc.language.isoen
dc.publisherROYAL SOC CHEMISTRY
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry
dc.subjectLIGHT-UP PROBE
dc.subjectCANCER-CHEMOTHERAPY
dc.subjectDRUG-DELIVERY
dc.subjectIN-VITRO
dc.subjectCELLS
dc.subjectAPOPTOSIS
dc.subjectBIOPROBE
dc.subjectSTRATEGY
dc.subjectABLATION
dc.subjectUPDATE
dc.typeArticle
dc.date.updated2020-06-11T07:40:15Z
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1039/c5sc00826c
dc.description.sourcetitleCHEMICAL SCIENCE
dc.description.volume6
dc.description.issue8
dc.description.page4580-4586
dc.published.statePublished
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