Please use this identifier to cite or link to this item:
https://doi.org/10.1039/c5sc00826c
DC Field | Value | |
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dc.title | Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics | |
dc.contributor.author | Zhang, Chong-Jing | |
dc.contributor.author | Hu, Qinglian | |
dc.contributor.author | Feng, Guangxue | |
dc.contributor.author | Zhang, Ruoyu | |
dc.contributor.author | Yuan, Youyong | |
dc.contributor.author | Lu, Xianmao | |
dc.contributor.author | Liu, Bin | |
dc.date.accessioned | 2020-06-15T03:08:21Z | |
dc.date.available | 2020-06-15T03:08:21Z | |
dc.date.issued | 2015-01-01 | |
dc.identifier.citation | Zhang, Chong-Jing, Hu, Qinglian, Feng, Guangxue, Zhang, Ruoyu, Yuan, Youyong, Lu, Xianmao, Liu, Bin (2015-01-01). Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics. CHEMICAL SCIENCE 6 (8) : 4580-4586. ScholarBank@NUS Repository. https://doi.org/10.1039/c5sc00826c | |
dc.identifier.issn | 20416520 | |
dc.identifier.issn | 20416539 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/169762 | |
dc.description.abstract | © The Royal Society of Chemistry. Subcellular targeted cancer therapy and in situ monitoring of therapeutic effect are highly desirable for clinical applications. Herein, we report a series of probes by conjugating zero (TPECM-2Br), one (TPECM-1TPP) and two (TPECM-2TPP) triphenylphosphine (TPP) ligands to a fluorogen with aggregation-induced emission (AIE) characteristics. The probes are almost non-emissive as molecularly dissolved species, but they can light up in cell cytoplasm or mitochondria. TPECM-2TPP is found to be able to target mitochondria, depolarize mitochondria membrane potential and selectively exert potent chemo-cytotoxicity on cancer cells. Furthermore, it can efficiently generate singlet oxygen with strong photo-toxicity upon light illumination, which further enhances its anti-cancer effect. On the other hand, TPECM-1TPP can also target mitochondria and generate singlet oxygen to trigger cancer cell apoptosis, but it shows low cytotoxicity in dark. Meanwhile, TPECM-1TPP can report the cellular oxidative stress by visualizing the morphological changes of mitochondria. However, TPECM-2Br does not target mitochondria and shows no obvious anticancer effect either in dark or under light illumination. This study thus highlights the importance of molecular probe design, which yields a new generation of subcellular targeted molecular theranostic agents with multi-function, such as cancer cell imaging, chemotherapy, photodynamic therapy, and in situ monitoring of the therapeutic effect in one go. | |
dc.language.iso | en | |
dc.publisher | ROYAL SOC CHEMISTRY | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Physical Sciences | |
dc.subject | Chemistry, Multidisciplinary | |
dc.subject | Chemistry | |
dc.subject | LIGHT-UP PROBE | |
dc.subject | CANCER-CHEMOTHERAPY | |
dc.subject | DRUG-DELIVERY | |
dc.subject | IN-VITRO | |
dc.subject | CELLS | |
dc.subject | APOPTOSIS | |
dc.subject | BIOPROBE | |
dc.subject | STRATEGY | |
dc.subject | ABLATION | |
dc.subject | UPDATE | |
dc.type | Article | |
dc.date.updated | 2020-06-11T07:40:15Z | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.doi | 10.1039/c5sc00826c | |
dc.description.sourcetitle | CHEMICAL SCIENCE | |
dc.description.volume | 6 | |
dc.description.issue | 8 | |
dc.description.page | 4580-4586 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Chem Sci-revised-Chongjing.pdf | Accepted version | 957.76 kB | Adobe PDF | OPEN | Post-print | View/Download |
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