Please use this identifier to cite or link to this item: https://doi.org/10.1002/adma.201601191
Title: Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage
Authors: CAI XIAOLEI 
Aishwarya Bandla 
MAO DUO 
FENG GUANGXUE 
Qin, Wei
LIAO LUN-DE 
Thakor, Nitish
Tang, Ben Zhong
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
LIGHT-UP BIOPROBE
CEREBRAL-ISCHEMIA
EVANS BLUE
IN-VITRO
PERMEABILITY
DOTS
PROTEINS
PHOTOTHROMBOSIS
DISRUPTION
MODULATION
Issue Date: 19-Oct-2016
Publisher: Wiley-VCH Verlag
Citation: CAI XIAOLEI, Aishwarya Bandla, MAO DUO, FENG GUANGXUE, Qin, Wei, LIAO LUN-DE, Thakor, Nitish, Tang, Ben Zhong, LIU BIN (2016-10-19). Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage. ADVANCED MATERIALS 28 (39) : 8760-8765. ScholarBank@NUS Repository. https://doi.org/10.1002/adma.201601191
Abstract: A fluorescence imaging method, based on 2,3-bis(4-(phenyl(4-(1,2,2-triphenylvinyl)phenyl)amino)-phenyl)fumaronitrile (TPETPAFN) nanoparticles (NPs) that could achieve sensitive and specific detection of blood-brain barrier (BBB) patency was studied. Modified nanoprecipitation method was applied to fabricate TPETPAFN NPs with controlled sizes. In a rat photothrombotic ischemia (PTI) model, the TPETPAFN NPs demonstrate the capacity for sensitive and specific monitoring of the BBB integrity. In vivo studies reveal that NPs with sizes greater than 30 nm do not extravasate, while NPs with the size of 10 nm could leak from nonischemic regions of the brain in the PTI model, although none of the NPs leak from the healthy brains. As a consequence, the 30 nm NPs could provide clear evaluation of vascular leakage at the exact location of brain stroke without nonspecific leakage at other intactregions, which show much higher specificity as compared to EB, the widely used method for the BBB damage evaluation.
Source Title: ADVANCED MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/169662
ISSN: 0935-9648
1521-4095
DOI: 10.1002/adma.201601191
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