Please use this identifier to cite or link to this item: https://doi.org/10.1002/adma.201601191
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dc.titleBiocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage
dc.contributor.authorCAI XIAOLEI
dc.contributor.authorAishwarya Bandla
dc.contributor.authorMAO DUO
dc.contributor.authorFENG GUANGXUE
dc.contributor.authorQin, Wei
dc.contributor.authorLIAO LUN-DE
dc.contributor.authorThakor, Nitish
dc.contributor.authorTang, Ben Zhong
dc.contributor.authorLIU BIN
dc.date.accessioned2020-06-11T06:30:07Z
dc.date.available2020-06-11T06:30:07Z
dc.date.issued2016-10-19
dc.identifier.citationCAI XIAOLEI, Aishwarya Bandla, MAO DUO, FENG GUANGXUE, Qin, Wei, LIAO LUN-DE, Thakor, Nitish, Tang, Ben Zhong, LIU BIN (2016-10-19). Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage. ADVANCED MATERIALS 28 (39) : 8760-8765. ScholarBank@NUS Repository. https://doi.org/10.1002/adma.201601191
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169662
dc.description.abstractA fluorescence imaging method, based on 2,3-bis(4-(phenyl(4-(1,2,2-triphenylvinyl)phenyl)amino)-phenyl)fumaronitrile (TPETPAFN) nanoparticles (NPs) that could achieve sensitive and specific detection of blood-brain barrier (BBB) patency was studied. Modified nanoprecipitation method was applied to fabricate TPETPAFN NPs with controlled sizes. In a rat photothrombotic ischemia (PTI) model, the TPETPAFN NPs demonstrate the capacity for sensitive and specific monitoring of the BBB integrity. In vivo studies reveal that NPs with sizes greater than 30 nm do not extravasate, while NPs with the size of 10 nm could leak from nonischemic regions of the brain in the PTI model, although none of the NPs leak from the healthy brains. As a consequence, the 30 nm NPs could provide clear evaluation of vascular leakage at the exact location of brain stroke without nonspecific leakage at other intactregions, which show much higher specificity as compared to EB, the widely used method for the BBB damage evaluation.
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectTechnology
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry, Physical
dc.subjectNanoscience & Nanotechnology
dc.subjectMaterials Science, Multidisciplinary
dc.subjectPhysics, Applied
dc.subjectPhysics, Condensed Matter
dc.subjectChemistry
dc.subjectScience & Technology - Other Topics
dc.subjectMaterials Science
dc.subjectPhysics
dc.subjectLIGHT-UP BIOPROBE
dc.subjectCEREBRAL-ISCHEMIA
dc.subjectEVANS BLUE
dc.subjectIN-VITRO
dc.subjectPERMEABILITY
dc.subjectDOTS
dc.subjectPROTEINS
dc.subjectPHOTOTHROMBOSIS
dc.subjectDISRUPTION
dc.subjectMODULATION
dc.typeArticle
dc.date.updated2020-06-10T08:40:15Z
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.1002/adma.201601191
dc.description.sourcetitleADVANCED MATERIALS
dc.description.volume28
dc.description.issue39
dc.description.page8760-8765
dc.published.statePublished
dc.grant.idR279-000-444-281
dc.grant.idR279-000-415-112
dc.grant.fundingagencyNational Research Foundation Singapore
dc.grant.fundingagencyNational University of Singapore
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