Please use this identifier to cite or link to this item: https://doi.org/10.1039/c6py00449k
Title: Light-responsive AIE nanoparticles with cytosolic drug release to overcome drug resistance in cancer cells
Authors: YUAN YOUYONG 
XU SHIDANG 
Zhang Chongjing 
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Polymer Science
AGGREGATION-INDUCED EMISSION
MULTIDRUG-RESISTANCE
IN-SITU
PHOTODYNAMIC ABLATION
THERAPEUTIC RESPONSES
BLOCK-COPOLYMER
CO-DELIVERY
PROBE
CHEMOTHERAPY
DOXORUBICIN
Issue Date: 1-Jan-2016
Publisher: Royal Society of Chemistry (RSC)
Citation: YUAN YOUYONG, XU SHIDANG, Zhang Chongjing, LIU BIN (2016-01-01). Light-responsive AIE nanoparticles with cytosolic drug release to overcome drug resistance in cancer cells. Polymer Chemistry 7 (21) : 3530-3539. ScholarBank@NUS Repository. https://doi.org/10.1039/c6py00449k
Abstract: The acquisition of resistance to chemotherapy is a major hurdle for successful cancer therapy. Herein, a new light-responsive drug delivery nanoparticle system is developed to overcome doxorubicin (DOX) resistance in breast cancer cells. The nanoparticles with high drug loading capacity are self-assembled from an amphiphilic polymer which is composed of a hydrophobic photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a biocompatible and hydrophilic poly(ethylene glycol) (PEG) conjugated via a reactive oxygen species (ROS) cleavable thioketal (TK) linker. The AIE PS makes the nanoparticles visible for high-quality imaging and capable of generating ROS upon light irradiation. When exposed to white light irradiation, the ROS generated from the PS could not only induce the endo-lysosomal membrane rupture, but also break the nanoparticles. This results in facilitated endo-lysosomal escape and triggered cytosol release of DOX, which can significantly improve intracellular DOX accumulation and retention in drug resistant MDA-MB-231 breast cancer cells. With light irradiation, the drug loaded nanoparticles can significantly inhibit the growth of DOX-resistant MDA-MB-231 cells. These results reveal that AIEgen based nanoparticles offer a potentially effective approach to overcome drug resistance in cancer cells.
Source Title: Polymer Chemistry
URI: https://scholarbank.nus.edu.sg/handle/10635/169651
ISSN: 1759-9954
1759-9962
DOI: 10.1039/c6py00449k
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