Please use this identifier to cite or link to this item: https://doi.org/10.1039/c6py00449k
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dc.titleLight-responsive AIE nanoparticles with cytosolic drug release to overcome drug resistance in cancer cells
dc.contributor.authorYUAN YOUYONG
dc.contributor.authorXU SHIDANG
dc.contributor.authorZhang Chongjing
dc.contributor.authorLIU BIN
dc.date.accessioned2020-06-11T03:01:28Z
dc.date.available2020-06-11T03:01:28Z
dc.date.issued2016-01-01
dc.identifier.citationYUAN YOUYONG, XU SHIDANG, Zhang Chongjing, LIU BIN (2016-01-01). Light-responsive AIE nanoparticles with cytosolic drug release to overcome drug resistance in cancer cells. Polymer Chemistry 7 (21) : 3530-3539. ScholarBank@NUS Repository. https://doi.org/10.1039/c6py00449k
dc.identifier.issn1759-9954
dc.identifier.issn1759-9962
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169651
dc.description.abstractThe acquisition of resistance to chemotherapy is a major hurdle for successful cancer therapy. Herein, a new light-responsive drug delivery nanoparticle system is developed to overcome doxorubicin (DOX) resistance in breast cancer cells. The nanoparticles with high drug loading capacity are self-assembled from an amphiphilic polymer which is composed of a hydrophobic photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a biocompatible and hydrophilic poly(ethylene glycol) (PEG) conjugated via a reactive oxygen species (ROS) cleavable thioketal (TK) linker. The AIE PS makes the nanoparticles visible for high-quality imaging and capable of generating ROS upon light irradiation. When exposed to white light irradiation, the ROS generated from the PS could not only induce the endo-lysosomal membrane rupture, but also break the nanoparticles. This results in facilitated endo-lysosomal escape and triggered cytosol release of DOX, which can significantly improve intracellular DOX accumulation and retention in drug resistant MDA-MB-231 breast cancer cells. With light irradiation, the drug loaded nanoparticles can significantly inhibit the growth of DOX-resistant MDA-MB-231 cells. These results reveal that AIEgen based nanoparticles offer a potentially effective approach to overcome drug resistance in cancer cells.
dc.language.isoen
dc.publisherRoyal Society of Chemistry (RSC)
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectPolymer Science
dc.subjectAGGREGATION-INDUCED EMISSION
dc.subjectMULTIDRUG-RESISTANCE
dc.subjectIN-SITU
dc.subjectPHOTODYNAMIC ABLATION
dc.subjectTHERAPEUTIC RESPONSES
dc.subjectBLOCK-COPOLYMER
dc.subjectCO-DELIVERY
dc.subjectPROBE
dc.subjectCHEMOTHERAPY
dc.subjectDOXORUBICIN
dc.typeArticle
dc.date.updated2020-06-10T08:22:19Z
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1039/c6py00449k
dc.description.sourcetitlePolymer Chemistry
dc.description.volume7
dc.description.issue21
dc.description.page3530-3539
dc.published.statePublished
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