Please use this identifier to cite or link to this item:
https://doi.org/10.1039/c6py00449k
DC Field | Value | |
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dc.title | Light-responsive AIE nanoparticles with cytosolic drug release to overcome drug resistance in cancer cells | |
dc.contributor.author | YUAN YOUYONG | |
dc.contributor.author | XU SHIDANG | |
dc.contributor.author | Zhang Chongjing | |
dc.contributor.author | LIU BIN | |
dc.date.accessioned | 2020-06-11T03:01:28Z | |
dc.date.available | 2020-06-11T03:01:28Z | |
dc.date.issued | 2016-01-01 | |
dc.identifier.citation | YUAN YOUYONG, XU SHIDANG, Zhang Chongjing, LIU BIN (2016-01-01). Light-responsive AIE nanoparticles with cytosolic drug release to overcome drug resistance in cancer cells. Polymer Chemistry 7 (21) : 3530-3539. ScholarBank@NUS Repository. https://doi.org/10.1039/c6py00449k | |
dc.identifier.issn | 1759-9954 | |
dc.identifier.issn | 1759-9962 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/169651 | |
dc.description.abstract | The acquisition of resistance to chemotherapy is a major hurdle for successful cancer therapy. Herein, a new light-responsive drug delivery nanoparticle system is developed to overcome doxorubicin (DOX) resistance in breast cancer cells. The nanoparticles with high drug loading capacity are self-assembled from an amphiphilic polymer which is composed of a hydrophobic photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a biocompatible and hydrophilic poly(ethylene glycol) (PEG) conjugated via a reactive oxygen species (ROS) cleavable thioketal (TK) linker. The AIE PS makes the nanoparticles visible for high-quality imaging and capable of generating ROS upon light irradiation. When exposed to white light irradiation, the ROS generated from the PS could not only induce the endo-lysosomal membrane rupture, but also break the nanoparticles. This results in facilitated endo-lysosomal escape and triggered cytosol release of DOX, which can significantly improve intracellular DOX accumulation and retention in drug resistant MDA-MB-231 breast cancer cells. With light irradiation, the drug loaded nanoparticles can significantly inhibit the growth of DOX-resistant MDA-MB-231 cells. These results reveal that AIEgen based nanoparticles offer a potentially effective approach to overcome drug resistance in cancer cells. | |
dc.language.iso | en | |
dc.publisher | Royal Society of Chemistry (RSC) | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Physical Sciences | |
dc.subject | Polymer Science | |
dc.subject | AGGREGATION-INDUCED EMISSION | |
dc.subject | MULTIDRUG-RESISTANCE | |
dc.subject | IN-SITU | |
dc.subject | PHOTODYNAMIC ABLATION | |
dc.subject | THERAPEUTIC RESPONSES | |
dc.subject | BLOCK-COPOLYMER | |
dc.subject | CO-DELIVERY | |
dc.subject | PROBE | |
dc.subject | CHEMOTHERAPY | |
dc.subject | DOXORUBICIN | |
dc.type | Article | |
dc.date.updated | 2020-06-10T08:22:19Z | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.doi | 10.1039/c6py00449k | |
dc.description.sourcetitle | Polymer Chemistry | |
dc.description.volume | 7 | |
dc.description.issue | 21 | |
dc.description.page | 3530-3539 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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C6PY00449K.docx | Accepted version | 3.41 MB | Microsoft Word XML | OPEN | Post-print | View/Download |
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