Please use this identifier to cite or link to this item: https://doi.org/10.3390/jcm9030623
Title: Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review
Authors: Pang, Junxiong 
Wang, Min Xian 
Ang, Ian Yi Han
Tan, Sharon Hui Xuan
Lewis, Ruth Frances 
Chen, Jacinta I-Pei 
Gutierrez, Ramona A
Gwee, Sylvia Xiao Wei 
Chua, Pearleen Ee Yong 
Yang, Qian 
Ng, Xian Yi 
Yap, Rowena KS 
Tan, Hao Yi
Teo, Yik Ying 
Tan, Chorh Chuan 
Cook, Alex R 
Yap, Jason Chin-Huat 
Hsu, Li Yang 
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
novel coronavirus
diagnostics
vaccine
treatments
global health
outbreak
MERS-CoV
SARS-CoV
RESPIRATORY SYNDROME CORONAVIRUS
SARS-CORONAVIRUS
CLINICAL VALIDATION
PCR ASSAYS
MERS-COV
INFECTION
ANTIBODY
REPLICATION
INHIBITION
PNEUMONIA
Issue Date: 1-Mar-2020
Publisher: MDPI
Citation: Pang, Junxiong, Wang, Min Xian, Ang, Ian Yi Han, Tan, Sharon Hui Xuan, Lewis, Ruth Frances, Chen, Jacinta I-Pei, Gutierrez, Ramona A, Gwee, Sylvia Xiao Wei, Chua, Pearleen Ee Yong, Yang, Qian, Ng, Xian Yi, Yap, Rowena KS, Tan, Hao Yi, Teo, Yik Ying, Tan, Chorh Chuan, Cook, Alex R, Yap, Jason Chin-Huat, Hsu, Li Yang (2020-03-01). Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review. JOURNAL OF CLINICAL MEDICINE 9 (3). ScholarBank@NUS Repository. https://doi.org/10.3390/jcm9030623
Abstract: Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. It is timely to systematically review the potential of these interventions, including those for Middle East respiratory syndrome-Coronavirus (MERS-CoV) and severe acute respiratory syndrome (SARS)-CoV, to guide policymakers globally on their prioritization of resources for research and development. A systematic search was carried out in three major electronic databases (PubMed, Embase and Cochrane Library) to identify published studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Supplementary strategies through Google Search and personal communications were used. A total of 27 studies fulfilled the criteria for review. Several laboratory protocols for confirmation of suspected 2019-nCoV cases using real-time reverse transcription polymerase chain reaction (RT-PCR) have been published. A commercial RT-PCR kit developed by the Beijing Genomic Institute is currently widely used in China and likely in Asia. However, serological assays as well as point-of-care testing kits have not been developed but are likely in the near future. Several vaccine candidates are in the pipeline. The likely earliest Phase 1 vaccine trial is a synthetic DNA-based candidate. A number of novel compounds as well as therapeutics licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV. Some are being tested in clinical trials against MERS-CoV and SARS-CoV, while others have been listed for clinical trials against 2019-nCoV. However, there are currently no effective specific antivirals or drug combinations supported by high-level evidence.
Source Title: JOURNAL OF CLINICAL MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/169014
ISSN: 20770383
20770383
DOI: 10.3390/jcm9030623
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