Please use this identifier to cite or link to this item: https://doi.org/10.3390/jcm9030623
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dc.titlePotential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review
dc.contributor.authorPang, Junxiong
dc.contributor.authorWang, Min Xian
dc.contributor.authorAng, Ian Yi Han
dc.contributor.authorTan, Sharon Hui Xuan
dc.contributor.authorLewis, Ruth Frances
dc.contributor.authorChen, Jacinta I-Pei
dc.contributor.authorGutierrez, Ramona A
dc.contributor.authorGwee, Sylvia Xiao Wei
dc.contributor.authorChua, Pearleen Ee Yong
dc.contributor.authorYang, Qian
dc.contributor.authorNg, Xian Yi
dc.contributor.authorYap, Rowena KS
dc.contributor.authorTan, Hao Yi
dc.contributor.authorTeo, Yik Ying
dc.contributor.authorTan, Chorh Chuan
dc.contributor.authorCook, Alex R
dc.contributor.authorYap, Jason Chin-Huat
dc.contributor.authorHsu, Li Yang
dc.date.accessioned2020-06-03T03:58:03Z
dc.date.available2020-06-03T03:58:03Z
dc.date.issued2020-03-01
dc.identifier.citationPang, Junxiong, Wang, Min Xian, Ang, Ian Yi Han, Tan, Sharon Hui Xuan, Lewis, Ruth Frances, Chen, Jacinta I-Pei, Gutierrez, Ramona A, Gwee, Sylvia Xiao Wei, Chua, Pearleen Ee Yong, Yang, Qian, Ng, Xian Yi, Yap, Rowena KS, Tan, Hao Yi, Teo, Yik Ying, Tan, Chorh Chuan, Cook, Alex R, Yap, Jason Chin-Huat, Hsu, Li Yang (2020-03-01). Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review. JOURNAL OF CLINICAL MEDICINE 9 (3). ScholarBank@NUS Repository. https://doi.org/10.3390/jcm9030623
dc.identifier.issn20770383
dc.identifier.issn20770383
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169014
dc.description.abstractRapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. It is timely to systematically review the potential of these interventions, including those for Middle East respiratory syndrome-Coronavirus (MERS-CoV) and severe acute respiratory syndrome (SARS)-CoV, to guide policymakers globally on their prioritization of resources for research and development. A systematic search was carried out in three major electronic databases (PubMed, Embase and Cochrane Library) to identify published studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Supplementary strategies through Google Search and personal communications were used. A total of 27 studies fulfilled the criteria for review. Several laboratory protocols for confirmation of suspected 2019-nCoV cases using real-time reverse transcription polymerase chain reaction (RT-PCR) have been published. A commercial RT-PCR kit developed by the Beijing Genomic Institute is currently widely used in China and likely in Asia. However, serological assays as well as point-of-care testing kits have not been developed but are likely in the near future. Several vaccine candidates are in the pipeline. The likely earliest Phase 1 vaccine trial is a synthetic DNA-based candidate. A number of novel compounds as well as therapeutics licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV. Some are being tested in clinical trials against MERS-CoV and SARS-CoV, while others have been listed for clinical trials against 2019-nCoV. However, there are currently no effective specific antivirals or drug combinations supported by high-level evidence.
dc.language.isoen
dc.publisherMDPI
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectMedicine, General & Internal
dc.subjectGeneral & Internal Medicine
dc.subjectnovel coronavirus
dc.subjectdiagnostics
dc.subjectvaccine
dc.subjecttreatments
dc.subjectglobal health
dc.subjectoutbreak
dc.subjectMERS-CoV
dc.subjectSARS-CoV
dc.subjectRESPIRATORY SYNDROME CORONAVIRUS
dc.subjectSARS-CORONAVIRUS
dc.subjectCLINICAL VALIDATION
dc.subjectPCR ASSAYS
dc.subjectMERS-COV
dc.subjectINFECTION
dc.subjectANTIBODY
dc.subjectREPLICATION
dc.subjectINHIBITION
dc.subjectPNEUMONIA
dc.typeReview
dc.date.updated2020-05-27T13:27:59Z
dc.contributor.departmentDEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH)
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.3390/jcm9030623
dc.description.sourcetitleJOURNAL OF CLINICAL MEDICINE
dc.description.volume9
dc.description.issue3
dc.published.statePublished
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