Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.antiviral.2016.01.002
Title: The development of therapeutic antibodies against dengue virus
Authors: GUNTUR FIBRIANSAH 
LOK SHEE MEI 
Keywords: Antibody
Dengue virus
Flavivirus
Neutralization mechanism
Therapeutic antibodies
Issue Date: 11-Jan-2016
Publisher: Elsevier B.V.
Citation: GUNTUR FIBRIANSAH, LOK SHEE MEI (2016-01-11). The development of therapeutic antibodies against dengue virus. Antiviral Research 128 : 7-19. ScholarBank@NUS Repository. https://doi.org/10.1016/j.antiviral.2016.01.002
Abstract: Dengue virus, a positive-sense RNA virus, is one of the major human pathogens transmitted by mosquitoes. However, no fully effective licensed dengue vaccines or therapeutics are currently available. Several potent neutralizing antibodies against DENV have been isolated from mice and humans, and the characterization of their properties by biochemical and biophysical methods have revealed important insights for development of therapeutic antibodies. In this review, we summarize recently reported antibody-antigen complex structures, their likely neutralization mechanisms and enhancement propensities, as well as their prophylactic and therapeutic capabilities in mouse models. This article forms part of a symposium on flavivirus drug discovery in the journal Antiviral Research.
Source Title: Antiviral Research
URI: https://scholarbank.nus.edu.sg/handle/10635/168494
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2016.01.002
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