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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.antiviral.2016.01.002
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dc.titleThe development of therapeutic antibodies against dengue virus
dc.contributor.authorGUNTUR FIBRIANSAH
dc.contributor.authorLOK SHEE MEI
dc.date.accessioned2020-05-27T07:13:42Z
dc.date.available2020-05-27T07:13:42Z
dc.date.issued2016-01-11
dc.identifier.citationGUNTUR FIBRIANSAH, LOK SHEE MEI (2016-01-11). The development of therapeutic antibodies against dengue virus. Antiviral Research 128 : 7-19. ScholarBank@NUS Repository. https://doi.org/10.1016/j.antiviral.2016.01.002
dc.identifier.issn0166-3542
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/168494
dc.description.abstractDengue virus, a positive-sense RNA virus, is one of the major human pathogens transmitted by mosquitoes. However, no fully effective licensed dengue vaccines or therapeutics are currently available. Several potent neutralizing antibodies against DENV have been isolated from mice and humans, and the characterization of their properties by biochemical and biophysical methods have revealed important insights for development of therapeutic antibodies. In this review, we summarize recently reported antibody-antigen complex structures, their likely neutralization mechanisms and enhancement propensities, as well as their prophylactic and therapeutic capabilities in mouse models. This article forms part of a symposium on flavivirus drug discovery in the journal Antiviral Research.
dc.description.urihttps://www-sciencedirect-com.libproxy1.nus.edu.sg/science/article/pii/S0166354216300043?via%3Dihub
dc.publisherElsevier B.V.
dc.subjectAntibody
dc.subjectDengue virus
dc.subjectFlavivirus
dc.subjectNeutralization mechanism
dc.subjectTherapeutic antibodies
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.antiviral.2016.01.002
dc.description.sourcetitleAntiviral Research
dc.description.volume128
dc.description.page7-19
dc.published.statePublished
dc.grant.idMOE2012-T3-1-008
dc.grant.fundingagencyMOE
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