Please use this identifier to cite or link to this item: https://doi.org/10.1002/biot.201800445
Title: Meta‐Omics‐ and Metabolic Modeling‐Assisted Deciphering of Human Microbiota Metabolism
Authors: Brendan Fu‐Long Sieow
Toni Juhani Nurminen
LING HUA 
Chang,Matthew Wook 
Keywords: Genome‐scale modeling
Human microbiota
Metabolic networks
Meta‐omics
Issue Date: 1-Sep-2019
Publisher: Wiley-VCH Verlag
Citation: Brendan Fu‐Long Sieow, Toni Juhani Nurminen, LING HUA, Chang,Matthew Wook (2019-09-01). Meta‐Omics‐ and Metabolic Modeling‐Assisted Deciphering of Human Microbiota Metabolism. Biotechnology Journal 14 (9) : e1800445. ScholarBank@NUS Repository. https://doi.org/10.1002/biot.201800445
Abstract: The human microbiota is a complex community of commensal, symbiotic, and pathogenic microbes that play a crucial role in maintaining the homeostasis of human health. Such a homeostasis is maintained through the collective functioning of enzymatic genes responsible for the production of metabolites, enabling the interaction and signaling within microbiota as well as between microbes and the human host. Understanding microbial genes, their associated chemistries and functions would be valuable for engineering systemic metabolic pathways within the microbiota to manage human health and diseases. Given that there are many unknown gene metabolic functions and interactions, increasing efforts have been made to gain insights into the underlying functions of microbiota metabolism. This can be achieved through culture-independent metagenomic approaches and metabolic modeling to simulate the microenvironment of human microbiota. In this article, the recent advances in metagenome mining and functional profiling for the discovery of the genetic and biochemical links in human microbiota metabolism as well as metabolic modeling for simulation and prediction of metabolic fluxes in the human microbiota are reviewed. This review provides useful insights into the understanding, reconstruction, and modulation of the human microbiota guided by the knowledge acquired from the basic understanding of the human microbiota metabolism.
Source Title: Biotechnology Journal
URI: https://scholarbank.nus.edu.sg/handle/10635/167909
ISSN: 1860-6768
1860-7314
DOI: 10.1002/biot.201800445
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