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Title: Efficacy of palliative bladder radiotherapy for hematuria in advanced bladder cancer using contemporary radiotherapy techniques
Authors: Tey, J 
Soon, YY 
Cheo, T 
Ooi, KH 
Ho, F 
Vellayappan, B 
Chia, D 
Tai, BC 
Keywords: Radiotherapy
bladder cancer
Issue Date: 1-Jan-2019
Publisher: International Institute of Anticancer Research
Citation: Tey, J, Soon, YY, Cheo, T, Ooi, KH, Ho, F, Vellayappan, B, Chia, D, Tai, BC (2019-01-01). Efficacy of palliative bladder radiotherapy for hematuria in advanced bladder cancer using contemporary radiotherapy techniques. In Vivo 33 (6) : 2161-2167. ScholarBank@NUS Repository.
Abstract: © 2019 International Institute of Anticancer Research. All rights reserved. Background/Aim: The aim of this study was to review the outcomes of palliative radiotherapy (RT) for hematuria treated with modern RT techniques. Patients and Methods: This was a retrospective cohort study. The primary endpoint was symptom response rate. Secondary endpoints included symptom recurrence rate, overall survival and treatment-related toxicity. Results: Median age was 82 years (range=36-98 years). Median biologically effective dose (BED) was 36 Gy. Sixty-seven percent of patients (39/58) responded to RT. The median survival duration was 5.6 months (range=0.02-47.6 months). One third (13/39) of responders had recurrence of hematuria. Competing Risk regression with death as the competing risk showed that patients treated with low BED regimen (<36 Gy) had 5.76 times the hazard of recurrence compared to high BED regimen (>36 Gy) (p=0.01). One patient (2%) developed grade 3 nausea and vomiting which required admission for intravenous hydration. Conclusion: BED regimens should be recommended as they are associated with a significantly lower rate of recurrent hematuria.
Source Title: In Vivo
ISSN: 0258851X
DOI: 10.21873/invivo.11718
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