Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pntd.0003025
Title: Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions
Authors: Whitehorn J.
Yacoub S.
Anders K.L.
Macareo L.R.
Cassetti M.C.
Nguyen Van V.C.
Shi P.-Y. 
Wills B.
Simmons C.P.
Keywords: Article
chemoprophylaxis
clinical practice
comorbidity
dengue
disease severity
disease transmission
fever
human
risk assessment
animal
chemoprophylaxis
clinical trial (topic)
dengue
mouse
rhesus monkey
antivirus agent
Animals
Antiviral Agents
Chemoprevention
Clinical Trials as Topic
Dengue
Humans
Macaca mulatta
Mice
Issue Date: 2014
Citation: Whitehorn J., Yacoub S., Anders K.L., Macareo L.R., Cassetti M.C., Nguyen Van V.C., Shi P.-Y., Wills B., Simmons C.P. (2014). Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions. PLoS Neglected Tropical Diseases 8 (8) : e3025. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0003025
Abstract: Dengue is the most common arboviral disease of humans. There is an unmet need for a therapeutic intervention that reduces the duration and severity of dengue symptoms and diminishes the likelihood of severe complications. To this end, there are active discovery efforts in industry and academia to develop interventions, with a focus on small molecule inhibitors of dengue virus replication that are suitable for therapy or chemoprophylaxis. Advancements in animal models of dengue virus infection together with the possibility of a dengue human infection model have further enhanced the platform for dengue drug discovery. Whilst drug discovery efforts gestate, there are ongoing clinical research designed to benefit today's patients, including trials of supportive care interventions, and descriptive studies that should improve the ability of clinicians to make an accurate diagnosis early in the illness course and to identify patients most at risk of progression to severe disease. This review provides a state of the art summary of dengue drug discovery, clinical trials, and supportive allied research and reflects discussions at the 2nd International Dengue Therapeutics Workshop held in Ho Chi Minh City, Vietnam, in December 2013. ? 2014, Public Library of Science. All rights reserved.
Source Title: PLoS Neglected Tropical Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/161940
ISSN: 19352727
DOI: 10.1371/journal.pntd.0003025
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