Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pntd.0003025
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dc.titleDengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions
dc.contributor.authorWhitehorn J.
dc.contributor.authorYacoub S.
dc.contributor.authorAnders K.L.
dc.contributor.authorMacareo L.R.
dc.contributor.authorCassetti M.C.
dc.contributor.authorNguyen Van V.C.
dc.contributor.authorShi P.-Y.
dc.contributor.authorWills B.
dc.contributor.authorSimmons C.P.
dc.date.accessioned2019-11-08T08:48:18Z
dc.date.available2019-11-08T08:48:18Z
dc.date.issued2014
dc.identifier.citationWhitehorn J., Yacoub S., Anders K.L., Macareo L.R., Cassetti M.C., Nguyen Van V.C., Shi P.-Y., Wills B., Simmons C.P. (2014). Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions. PLoS Neglected Tropical Diseases 8 (8) : e3025. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0003025
dc.identifier.issn19352727
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161940
dc.description.abstractDengue is the most common arboviral disease of humans. There is an unmet need for a therapeutic intervention that reduces the duration and severity of dengue symptoms and diminishes the likelihood of severe complications. To this end, there are active discovery efforts in industry and academia to develop interventions, with a focus on small molecule inhibitors of dengue virus replication that are suitable for therapy or chemoprophylaxis. Advancements in animal models of dengue virus infection together with the possibility of a dengue human infection model have further enhanced the platform for dengue drug discovery. Whilst drug discovery efforts gestate, there are ongoing clinical research designed to benefit today's patients, including trials of supportive care interventions, and descriptive studies that should improve the ability of clinicians to make an accurate diagnosis early in the illness course and to identify patients most at risk of progression to severe disease. This review provides a state of the art summary of dengue drug discovery, clinical trials, and supportive allied research and reflects discussions at the 2nd International Dengue Therapeutics Workshop held in Ho Chi Minh City, Vietnam, in December 2013. ? 2014, Public Library of Science. All rights reserved.
dc.sourceUnpaywall 20191101
dc.subjectArticle
dc.subjectchemoprophylaxis
dc.subjectclinical practice
dc.subjectcomorbidity
dc.subjectdengue
dc.subjectdisease severity
dc.subjectdisease transmission
dc.subjectfever
dc.subjecthuman
dc.subjectrisk assessment
dc.subjectanimal
dc.subjectchemoprophylaxis
dc.subjectclinical trial (topic)
dc.subjectdengue
dc.subjectmouse
dc.subjectrhesus monkey
dc.subjectantivirus agent
dc.subjectAnimals
dc.subjectAntiviral Agents
dc.subjectChemoprevention
dc.subjectClinical Trials as Topic
dc.subjectDengue
dc.subjectHumans
dc.subjectMacaca mulatta
dc.subjectMice
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1371/journal.pntd.0003025
dc.description.sourcetitlePLoS Neglected Tropical Diseases
dc.description.volume8
dc.description.issue8
dc.description.pagee3025
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