Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.molmed.2019.02.004
Title: Annexin-A1 - A Blessing or a Curse in Cancer?
Authors: Foo, Sok Lin
YAP LI REN GRACEMARY 
Cui Jianzhou 
LIM HSIU KIM,LINA 
Keywords: cancer
metastasis
proliferation
Issue Date: Apr-2019
Publisher: Elsevier Science Ltd
Citation: Foo, Sok Lin, YAP LI REN GRACEMARY, Cui Jianzhou, LIM HSIU KIM,LINA (2019-04). Annexin-A1 - A Blessing or a Curse in Cancer?. Trends in molecular medicine. 25 (4) : 315-327. ScholarBank@NUS Repository. https://doi.org/10.1016/j.molmed.2019.02.004
Abstract: Annexin-A1 (ANXA1), a potent endogenous immunomodulatory protein has been implicated in multiple functions essential in cancer, including cell proliferation, apoptosis, chemosensitivity, metastasis, and invasion. ANXA1 expression is varied depending on tumor type, and there are contradictory reports on its role in the regulation of proliferation and tumor growth. Here, we summarize the differing reports on cell proliferation and metastasis and attempt to discuss the reasons behind these different effects. ANXA1 plays a role as a homeostatic protein that regulates essential transcription factors and miRNAs. A more coherent understanding of ANXA1 in cancer could present a more biologically meaningful and clinically relevant strategy.
Source Title: Trends in molecular medicine.
URI: https://scholarbank.nus.edu.sg/handle/10635/160645
ISSN: 1471-4914
1471-499X
DOI: 10.1016/j.molmed.2019.02.004
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