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Title: Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells.
Authors: Kandilya, Deepika
Maskomani, Silambarasan 
Shyamasundar, Sukanya
Tambyah, Paul Anantharajah 
Shiao Yng, Chan 
Lee, Regina Ching Hua 
Hande, Manoor Prakash 
Mallilankaraman, Karthik 
Chu, Justin Jang Hann 
Dheen, S Thameem 
Keywords: DNA methylation
Hippo signaling
Zika virus
human neural progenitor cells
stemness and differentiation
Issue Date: 25-Jun-2019
Citation: Kandilya, Deepika, Maskomani, Silambarasan, Shyamasundar, Sukanya, Tambyah, Paul Anantharajah, Shiao Yng, Chan, Lee, Regina Ching Hua, Hande, Manoor Prakash, Mallilankaraman, Karthik, Chu, Justin Jang Hann, Dheen, S Thameem (2019-06-25). Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells.. Epigenomics. ScholarBank@NUS Repository.
Abstract: Aim: This study was aimed to understand if Zika virus (ZIKV) alters the DNA methylome of human neural progenitor cells (hNPCs). Materials & methods: Whole genome DNA methylation profiling was performed using human methylationEPIC array in control and ZIKV infected hNPCs. Results & conclusion: ZIKV infection altered the DNA methylation of several genes such as WWTR1 (TAZ) and RASSF1 of Hippo signaling pathway which regulates organ size during brain development, and decreased the expression of several centrosomal-related microcephaly genes, and genes involved in stemness and differentiation in human neural progenitor cells. Overall, ZIKV downregulated the Hippo signaling pathway genes which perturb the stemness and differentiation process in hNPCs, which could form the basis for ZIKV-induced microcephaly.
Source Title: Epigenomics
ISSN: 1750-1911
DOI: 10.2217/epi-2018-0180
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