Please use this identifier to cite or link to this item: https://doi.org/10.2217/epi-2018-0180
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dc.titleZika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells.
dc.contributor.authorKandilya, Deepika
dc.contributor.authorMaskomani, Silambarasan
dc.contributor.authorShyamasundar, Sukanya
dc.contributor.authorTambyah, Paul Anantharajah
dc.contributor.authorShiao Yng, Chan
dc.contributor.authorLee, Regina Ching Hua
dc.contributor.authorHande, Manoor Prakash
dc.contributor.authorMallilankaraman, Karthik
dc.contributor.authorChu, Justin Jang Hann
dc.contributor.authorDheen, S Thameem
dc.date.accessioned2019-07-15T01:24:55Z
dc.date.available2019-07-15T01:24:55Z
dc.date.issued2019-06-25
dc.identifier.citationKandilya, Deepika, Maskomani, Silambarasan, Shyamasundar, Sukanya, Tambyah, Paul Anantharajah, Shiao Yng, Chan, Lee, Regina Ching Hua, Hande, Manoor Prakash, Mallilankaraman, Karthik, Chu, Justin Jang Hann, Dheen, S Thameem (2019-06-25). Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells.. Epigenomics. ScholarBank@NUS Repository. https://doi.org/10.2217/epi-2018-0180
dc.identifier.issn1750-1911
dc.identifier.issn1750-192X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/156623
dc.description.abstractAim: This study was aimed to understand if Zika virus (ZIKV) alters the DNA methylome of human neural progenitor cells (hNPCs). Materials & methods: Whole genome DNA methylation profiling was performed using human methylationEPIC array in control and ZIKV infected hNPCs. Results & conclusion: ZIKV infection altered the DNA methylation of several genes such as WWTR1 (TAZ) and RASSF1 of Hippo signaling pathway which regulates organ size during brain development, and decreased the expression of several centrosomal-related microcephaly genes, and genes involved in stemness and differentiation in human neural progenitor cells. Overall, ZIKV downregulated the Hippo signaling pathway genes which perturb the stemness and differentiation process in hNPCs, which could form the basis for ZIKV-induced microcephaly.
dc.sourceElements
dc.subjectDNA methylation
dc.subjectHippo signaling
dc.subjectRASSF1
dc.subjectYAP/TAZ
dc.subjectZika virus
dc.subjecthuman neural progenitor cells
dc.subjectmicrocephaly
dc.subjectstemness and differentiation
dc.typeArticle
dc.date.updated2019-07-12T15:29:45Z
dc.contributor.departmentDEPT OF ANATOMY
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.contributor.departmentDEPT OF MICROBIOLOGY & IMMUNOLOGY
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.description.doi10.2217/epi-2018-0180
dc.description.sourcetitleEpigenomics
dc.published.statePublished online
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