Please use this identifier to cite or link to this item:
https://doi.org/10.2217/epi-2018-0180
DC Field | Value | |
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dc.title | Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells. | |
dc.contributor.author | Kandilya, Deepika | |
dc.contributor.author | Maskomani, Silambarasan | |
dc.contributor.author | Shyamasundar, Sukanya | |
dc.contributor.author | Tambyah, Paul Anantharajah | |
dc.contributor.author | Shiao Yng, Chan | |
dc.contributor.author | Lee, Regina Ching Hua | |
dc.contributor.author | Hande, Manoor Prakash | |
dc.contributor.author | Mallilankaraman, Karthik | |
dc.contributor.author | Chu, Justin Jang Hann | |
dc.contributor.author | Dheen, S Thameem | |
dc.date.accessioned | 2019-07-15T01:24:55Z | |
dc.date.available | 2019-07-15T01:24:55Z | |
dc.date.issued | 2019-06-25 | |
dc.identifier.citation | Kandilya, Deepika, Maskomani, Silambarasan, Shyamasundar, Sukanya, Tambyah, Paul Anantharajah, Shiao Yng, Chan, Lee, Regina Ching Hua, Hande, Manoor Prakash, Mallilankaraman, Karthik, Chu, Justin Jang Hann, Dheen, S Thameem (2019-06-25). Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells.. Epigenomics. ScholarBank@NUS Repository. https://doi.org/10.2217/epi-2018-0180 | |
dc.identifier.issn | 1750-1911 | |
dc.identifier.issn | 1750-192X | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/156623 | |
dc.description.abstract | Aim: This study was aimed to understand if Zika virus (ZIKV) alters the DNA methylome of human neural progenitor cells (hNPCs). Materials & methods: Whole genome DNA methylation profiling was performed using human methylationEPIC array in control and ZIKV infected hNPCs. Results & conclusion: ZIKV infection altered the DNA methylation of several genes such as WWTR1 (TAZ) and RASSF1 of Hippo signaling pathway which regulates organ size during brain development, and decreased the expression of several centrosomal-related microcephaly genes, and genes involved in stemness and differentiation in human neural progenitor cells. Overall, ZIKV downregulated the Hippo signaling pathway genes which perturb the stemness and differentiation process in hNPCs, which could form the basis for ZIKV-induced microcephaly. | |
dc.source | Elements | |
dc.subject | DNA methylation | |
dc.subject | Hippo signaling | |
dc.subject | RASSF1 | |
dc.subject | YAP/TAZ | |
dc.subject | Zika virus | |
dc.subject | human neural progenitor cells | |
dc.subject | microcephaly | |
dc.subject | stemness and differentiation | |
dc.type | Article | |
dc.date.updated | 2019-07-12T15:29:45Z | |
dc.contributor.department | ANATOMY | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.2217/epi-2018-0180 | |
dc.description.sourcetitle | Epigenomics | |
dc.published.state | Published online | |
Appears in Collections: | Staff Publications Elements Students Publications |
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