Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-019-41296-w
Title: Effects of low and moderate refractive errors on chromatic pupillometry
Authors: RUKMINI, AV 
CHEW, MILTON C
FINKELSTEIN, MAXWELL T
ATALAY, ERAY
BASKARAN, MANI 
NONGPIUR, MONISHA E 
GOOLEY, JOSHUA J 
AUNG, TIN 
MILEA, DAN 
NAJJAR, RAYMOND P 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
ILLUMINATION PUPIL RESPONSE
RETINAL GANGLION-CELLS
FLICKER PHOTOMETRY
MELANOPSIN
LIGHT
CONE
PREVALENCE
MYOPIA
ROD
POPULATION
Issue Date: 20-Mar-2019
Publisher: NATURE PUBLISHING GROUP
Citation: RUKMINI, AV, CHEW, MILTON C, FINKELSTEIN, MAXWELL T, ATALAY, ERAY, BASKARAN, MANI, NONGPIUR, MONISHA E, GOOLEY, JOSHUA J, AUNG, TIN, MILEA, DAN, NAJJAR, RAYMOND P (2019-03-20). Effects of low and moderate refractive errors on chromatic pupillometry. SCIENTIFIC REPORTS 9 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-019-41296-w
Abstract: © 2019, The Author(s). Chromatic pupillometry is an emerging modality in the assessment of retinal and optic nerve disorders. Herein, we evaluate the effect of low and moderate refractive errors on pupillary responses to blue- and red-light stimuli in a healthy older population. This study included 139 participants (≥50 years) grouped by refractive error: moderate myopes (>−6.0D and ≤−3.0D, n = 24), low myopes (>−3.0D and <−0.5D, n = 30), emmetropes (≥−0.5D and ≤0.5D, n = 31) and hyperopes (>0.5D and <6.0D, n = 54). Participants were exposed to logarithmically ramping-up blue (462 nm) and red (638 nm) light stimuli, designed to sequentially activate rods, cones and intrinsically-photosensitive retinal ganglion cells. Pupil size was assessed monocularly using infra-red pupillography. Baseline pupil diameter correlated inversely with spherical equivalent (R = −0.26, P < 0.01), and positively with axial length (R = 0.37, P < 0.01) and anterior chamber depth (R = 0.43, P < 0.01). Baseline-adjusted pupillary constriction amplitudes to blue light did not differ between groups (P = 0.45), while constriction amplitudes to red light were greater in hyperopes compared to emmetropes (P = 0.04) at moderate to bright light intensities (12.25–14.0 Log photons/cm²/s). Our results demonstrate that low and moderate myopia do not alter pupillary responses to ramping-up blue- and red-light stimuli in healthy older individuals. Conversely, pupillary responses to red light should be interpreted cautiously in hyperopic eyes.
Source Title: SCIENTIFIC REPORTS
URI: https://scholarbank.nus.edu.sg/handle/10635/155336
ISSN: 20452322
DOI: 10.1038/s41598-019-41296-w
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