Please use this identifier to cite or link to this item: https://doi.org/10.1530/EC-17-0359
Title: Effect of gestational diabetes and hypertensive disorders of pregnancy on postpartum cardiometabolic risk
Authors: Li, LJ 
Aris, IM 
Su, LL 
Chong, YS 
Wong, TY 
Tan, KH 
Wang, JJ 
Keywords: abnormal glucose metabolism
cardio-metabolic disease
gestational diabetes mellitus
hypertension
hypertensive disorders of pregnancy
metabolic syndrome
Issue Date: 1-Mar-2018
Publisher: Bioscientifica
Citation: Li, LJ, Aris, IM, Su, LL, Chong, YS, Wong, TY, Tan, KH, Wang, JJ (2018-03-01). Effect of gestational diabetes and hypertensive disorders of pregnancy on postpartum cardiometabolic risk. Endocrine Connections 7 (3) : 433-442. ScholarBank@NUS Repository. https://doi.org/10.1530/EC-17-0359
Abstract: © 2018 The authors. Aims: The cumulative effect of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) on postpartum cardio-metabolic diseases is equivocal. We aimed to assess the associations of GDM and HDP’s individual and synergic contribution to risks of postpartum cardio-metabolic diseases (metabolic syndrome (MetS), abnormal glucose metabolism and hypertension (HTN)). Methods: Of participants from a Singapore birth cohort, 276 mothers attending the 5-year postpartum visit were included in this study. During this visit, we collected mothers’ history of GDM and HDP in all live births in a chronicle sequence and assessed the cardio-metabolic risks based on blood pressure, anthropometry and a panel of serum biomarkers. We diagnosed MetS, abnormal glucose metabolism and HTN according to Adult Treatment Panel III 2000 and World Health Organization guidelines. Results: Of 276 mothers, 157 (56.9%) had histories of GDM while 23 (8.3%) had histories of HDP. After full adjustment, we found associations of GDM episodes with postpartum abnormal glucose metabolism (single episode: relative risk (RR) 2.9 (95% CI: 1.7, 4.8); recurrent episodes (≥2): RR = 3.8 (2.1-6.8)). Also, we found association between histories of HDP and HTN (RR = 3.6 (1.5, 8.6)). Having either (RR 2.6 (1.7-3.9)) or both gestational complications (RR 2.7 (1.6-4.9)) was associated with similar risk of postpartum cardiometabolic disease. Conclusions: Mothers with GDM or HDP had a threefold increased risk of postpartum abnormal glucose metabolism or HTN, respectively. Having both GDM and HDP during past pregnancies was not associated with additional risk of postpartum cardio-metabolic diseases beyond that associated with either complication alone.
Source Title: Endocrine Connections
URI: https://scholarbank.nus.edu.sg/handle/10635/155023
ISSN: 2049-3614
2049-3614
DOI: 10.1530/EC-17-0359
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