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https://doi.org/10.1038/35036600
Title: | Memory B-cell persistence is independent of persisting immunizing antigen | Authors: | Maruyama, M. Lam, K.-P. Rajewsky, K. |
Issue Date: | 5-Oct-2000 | Citation: | Maruyama, M., Lam, K.-P., Rajewsky, K. (2000-10-05). Memory B-cell persistence is independent of persisting immunizing antigen. Nature 407 (6804) : 636-642. ScholarBank@NUS Repository. https://doi.org/10.1038/35036600 | Abstract: | Immunological memory in the antibody system is generated in T-cell-dependent responses and carried by long-lived memory B cells that recognize antigen by high-affinity antibodies. But it remains controversial whether these B cells represent true 'memory' cells (that is, their maintenance is independent of the immunizing antigen), or whether they are a product of a chronic immune response driven by the immunizing antigen, which can be retained in the organism for extended time periods on the surface of specialized antigen-presenting cells (follicular dendritic cells). Cell transfer experiments provided evidence in favour of a role of the immunizing antigen; however, analysis of memory cells in intact animals, which showed that these cells are mostly resting and can persist in the absence of detectable T-cell help or follicular dendritic cells, argued against it. Here we show, by using a genetic switch mediated by Cre recombinase, that memory B cells switching their antibody specificity away from the immunizing antigen are indeed maintained in the animal over long periods of time, similar to cells retaining their original antigen-binding specificity. | Source Title: | Nature | URI: | http://scholarbank.nus.edu.sg/handle/10635/132641 | ISSN: | 00280836 | DOI: | 10.1038/35036600 |
Appears in Collections: | Staff Publications |
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