Please use this identifier to cite or link to this item: https://doi.org/10.1038/35036600
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dc.titleMemory B-cell persistence is independent of persisting immunizing antigen
dc.contributor.authorMaruyama, M.
dc.contributor.authorLam, K.-P.
dc.contributor.authorRajewsky, K.
dc.date.accessioned2016-12-13T05:34:48Z
dc.date.available2016-12-13T05:34:48Z
dc.date.issued2000-10-05
dc.identifier.citationMaruyama, M., Lam, K.-P., Rajewsky, K. (2000-10-05). Memory B-cell persistence is independent of persisting immunizing antigen. Nature 407 (6804) : 636-642. ScholarBank@NUS Repository. https://doi.org/10.1038/35036600
dc.identifier.issn00280836
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/132641
dc.description.abstractImmunological memory in the antibody system is generated in T-cell-dependent responses and carried by long-lived memory B cells that recognize antigen by high-affinity antibodies. But it remains controversial whether these B cells represent true 'memory' cells (that is, their maintenance is independent of the immunizing antigen), or whether they are a product of a chronic immune response driven by the immunizing antigen, which can be retained in the organism for extended time periods on the surface of specialized antigen-presenting cells (follicular dendritic cells). Cell transfer experiments provided evidence in favour of a role of the immunizing antigen; however, analysis of memory cells in intact animals, which showed that these cells are mostly resting and can persist in the absence of detectable T-cell help or follicular dendritic cells, argued against it. Here we show, by using a genetic switch mediated by Cre recombinase, that memory B cells switching their antibody specificity away from the immunizing antigen are indeed maintained in the animal over long periods of time, similar to cells retaining their original antigen-binding specificity.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/35036600
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPAEDIATRICS
dc.description.doi10.1038/35036600
dc.description.sourcetitleNature
dc.description.volume407
dc.description.issue6804
dc.description.page636-642
dc.description.codenNATUA
dc.identifier.isiut000089772800049
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