Please use this identifier to cite or link to this item:
|Title:||Memory B-cell persistence is independent of persisting immunizing antigen|
|Citation:||Maruyama, M., Lam, K.-P., Rajewsky, K. (2000-10-05). Memory B-cell persistence is independent of persisting immunizing antigen. Nature 407 (6804) : 636-642. ScholarBank@NUS Repository. https://doi.org/10.1038/35036600|
|Abstract:||Immunological memory in the antibody system is generated in T-cell-dependent responses and carried by long-lived memory B cells that recognize antigen by high-affinity antibodies. But it remains controversial whether these B cells represent true 'memory' cells (that is, their maintenance is independent of the immunizing antigen), or whether they are a product of a chronic immune response driven by the immunizing antigen, which can be retained in the organism for extended time periods on the surface of specialized antigen-presenting cells (follicular dendritic cells). Cell transfer experiments provided evidence in favour of a role of the immunizing antigen; however, analysis of memory cells in intact animals, which showed that these cells are mostly resting and can persist in the absence of detectable T-cell help or follicular dendritic cells, argued against it. Here we show, by using a genetic switch mediated by Cre recombinase, that memory B cells switching their antibody specificity away from the immunizing antigen are indeed maintained in the animal over long periods of time, similar to cells retaining their original antigen-binding specificity.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 12, 2018
WEB OF SCIENCETM
checked on Dec 4, 2018
checked on Sep 27, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.