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Title: St. John's wort modulates the toxicities and pharmacokinetics of CPT-11 (Irinotecan) in rats
Authors: Hu, Z.
Yang, X.
Ho, P.C.-L. 
Chan, E. 
Sui, Y.C. 
Xu, C.
Li, X.
Zhu, Y.-Z.
Duan, W.
Chen, X.
Huang, M.
Yang, H.
Zhou, S. 
Keywords: CPT-11
St. John's wort
Issue Date: Jun-2005
Citation: Hu, Z., Yang, X., Ho, P.C.-L., Chan, E., Sui, Y.C., Xu, C., Li, X., Zhu, Y.-Z., Duan, W., Chen, X., Huang, M., Yang, H., Zhou, S. (2005-06). St. John's wort modulates the toxicities and pharmacokinetics of CPT-11 (Irinotecan) in rats. Pharmaceutical Research 22 (6) : 902-914. ScholarBank@NUS Repository.
Abstract: Purpose. CPT-11 is a DNA topoisomerase I inhibitor for the therapy of colorectal cancer, whereas St. John's Wort (Hypericum perforatum, SJW) is a widely used herbal anti-depressant. This study aimed to investigate the effects of co-administered SJW on the toxicities and pharmacokinetics of CPT-11 and the underlying mechanisms. Methods. The body weight loss, gastrointestinal and hematological toxicities induced by CPT-11, and the pharmacokinetic parameters of CPT-11 were evaluated in rats pretreated with SJW or vehicle. Results. Rats treated with CPT-11 alone experienced rapid decrease in body weight, whereas co-administration of SJW with CPT-11 resulted in lesser body weight loss. The gastrointestinal and hematological toxicities following CPT-11 injection were both alleviated in the presence of SJW. The rat pharmacokinetics of both CPT-11 and its metabolite SN-38 were significantly altered in presence of SJW. Conclusions. In conclusion, co-administered SJW significantly ameliorated the toxicities induced by CPT-11. The protective effect of SJW may be partially due to pharmacokinetic interaction between CPT-11 and SJW. © 2005 Springer Science + Business Media, Inc.
Source Title: Pharmaceutical Research
ISSN: 07248741
DOI: 10.1007/s11095-005-4585-0
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