Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11095-005-4585-0
Title: St. John's wort modulates the toxicities and pharmacokinetics of CPT-11 (Irinotecan) in rats
Authors: Hu, Z.
Yang, X.
Ho, P.C.-L. 
Chan, E. 
Sui, Y.C. 
Xu, C.
Li, X.
Zhu, Y.-Z.
Duan, W.
Chen, X.
Huang, M.
Yang, H.
Zhou, S. 
Keywords: CPT-11
Pharmacokinetics
St. John's wort
Toxicity
Issue Date: Jun-2005
Citation: Hu, Z., Yang, X., Ho, P.C.-L., Chan, E., Sui, Y.C., Xu, C., Li, X., Zhu, Y.-Z., Duan, W., Chen, X., Huang, M., Yang, H., Zhou, S. (2005-06). St. John's wort modulates the toxicities and pharmacokinetics of CPT-11 (Irinotecan) in rats. Pharmaceutical Research 22 (6) : 902-914. ScholarBank@NUS Repository. https://doi.org/10.1007/s11095-005-4585-0
Abstract: Purpose. CPT-11 is a DNA topoisomerase I inhibitor for the therapy of colorectal cancer, whereas St. John's Wort (Hypericum perforatum, SJW) is a widely used herbal anti-depressant. This study aimed to investigate the effects of co-administered SJW on the toxicities and pharmacokinetics of CPT-11 and the underlying mechanisms. Methods. The body weight loss, gastrointestinal and hematological toxicities induced by CPT-11, and the pharmacokinetic parameters of CPT-11 were evaluated in rats pretreated with SJW or vehicle. Results. Rats treated with CPT-11 alone experienced rapid decrease in body weight, whereas co-administration of SJW with CPT-11 resulted in lesser body weight loss. The gastrointestinal and hematological toxicities following CPT-11 injection were both alleviated in the presence of SJW. The rat pharmacokinetics of both CPT-11 and its metabolite SN-38 were significantly altered in presence of SJW. Conclusions. In conclusion, co-administered SJW significantly ameliorated the toxicities induced by CPT-11. The protective effect of SJW may be partially due to pharmacokinetic interaction between CPT-11 and SJW. © 2005 Springer Science + Business Media, Inc.
Source Title: Pharmaceutical Research
URI: http://scholarbank.nus.edu.sg/handle/10635/106355
ISSN: 07248741
DOI: 10.1007/s11095-005-4585-0
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

33
checked on May 19, 2018

WEB OF SCIENCETM
Citations

31
checked on Apr 3, 2018

Page view(s)

25
checked on Apr 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.