Please use this identifier to cite or link to this item:
https://doi.org/10.1002/bimj.200410057
Title: | Robust tests for candidate-gene association using case-parents trios with a multi-allelic marker | Authors: | Zheng, G. Chen, Z. |
Keywords: | Genetic models Maximum tests Multiple alleles Power Robustness |
Issue Date: | Sep-2004 | Citation: | Zheng, G., Chen, Z. (2004-09). Robust tests for candidate-gene association using case-parents trios with a multi-allelic marker. Biometrical Journal 46 (5) : 606-611. ScholarBank@NUS Repository. https://doi.org/10.1002/bimj.200410057 | Abstract: | In case-parents trios design, the association between a multi-allelic candidate-gene and a disease can be detected by using maximum of score tests (max-score) when the mode of inheritance is known. We apply the maximum of the max-score statistics and the maximum of likelihood ratio statistics when the genetic model is unknown and examine their robust properties compared to max-score statistics. The simulation results demonstrate that the two maximum robust tests are more efficacious and robust across all genetic models compared with the three max-score tests. Moreover, in most situations, the maximum of the max-score tests seems to be more powerful than the maximum of the likelihood ratio tests. | Source Title: | Biometrical Journal | URI: | http://scholarbank.nus.edu.sg/handle/10635/105339 | ISSN: | 03233847 | DOI: | 10.1002/bimj.200410057 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.