Please use this identifier to cite or link to this item:
https://doi.org/10.1002/bimj.200410057
DC Field | Value | |
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dc.title | Robust tests for candidate-gene association using case-parents trios with a multi-allelic marker | |
dc.contributor.author | Zheng, G. | |
dc.contributor.author | Chen, Z. | |
dc.date.accessioned | 2014-10-28T05:14:48Z | |
dc.date.available | 2014-10-28T05:14:48Z | |
dc.date.issued | 2004-09 | |
dc.identifier.citation | Zheng, G., Chen, Z. (2004-09). Robust tests for candidate-gene association using case-parents trios with a multi-allelic marker. Biometrical Journal 46 (5) : 606-611. ScholarBank@NUS Repository. https://doi.org/10.1002/bimj.200410057 | |
dc.identifier.issn | 03233847 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/105339 | |
dc.description.abstract | In case-parents trios design, the association between a multi-allelic candidate-gene and a disease can be detected by using maximum of score tests (max-score) when the mode of inheritance is known. We apply the maximum of the max-score statistics and the maximum of likelihood ratio statistics when the genetic model is unknown and examine their robust properties compared to max-score statistics. The simulation results demonstrate that the two maximum robust tests are more efficacious and robust across all genetic models compared with the three max-score tests. Moreover, in most situations, the maximum of the max-score tests seems to be more powerful than the maximum of the likelihood ratio tests. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/bimj.200410057 | |
dc.source | Scopus | |
dc.subject | Genetic models | |
dc.subject | Maximum tests | |
dc.subject | Multiple alleles | |
dc.subject | Power | |
dc.subject | Robustness | |
dc.type | Article | |
dc.contributor.department | STATISTICS & APPLIED PROBABILITY | |
dc.description.doi | 10.1002/bimj.200410057 | |
dc.description.sourcetitle | Biometrical Journal | |
dc.description.volume | 46 | |
dc.description.issue | 5 | |
dc.description.page | 606-611 | |
dc.identifier.isiut | 000224795100013 | |
Appears in Collections: | Staff Publications |
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