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|Title:||Robust tests for candidate-gene association using case-parents trios with a multi-allelic marker|
|Citation:||Zheng, G., Chen, Z. (2004-09). Robust tests for candidate-gene association using case-parents trios with a multi-allelic marker. Biometrical Journal 46 (5) : 606-611. ScholarBank@NUS Repository. https://doi.org/10.1002/bimj.200410057|
|Abstract:||In case-parents trios design, the association between a multi-allelic candidate-gene and a disease can be detected by using maximum of score tests (max-score) when the mode of inheritance is known. We apply the maximum of the max-score statistics and the maximum of likelihood ratio statistics when the genetic model is unknown and examine their robust properties compared to max-score statistics. The simulation results demonstrate that the two maximum robust tests are more efficacious and robust across all genetic models compared with the three max-score tests. Moreover, in most situations, the maximum of the max-score tests seems to be more powerful than the maximum of the likelihood ratio tests.|
|Source Title:||Biometrical Journal|
|Appears in Collections:||Staff Publications|
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