Please use this identifier to cite or link to this item: https://doi.org/10.1002/bimj.200410057
Title: Robust tests for candidate-gene association using case-parents trios with a multi-allelic marker
Authors: Zheng, G.
Chen, Z. 
Keywords: Genetic models
Maximum tests
Multiple alleles
Power
Robustness
Issue Date: Sep-2004
Citation: Zheng, G., Chen, Z. (2004-09). Robust tests for candidate-gene association using case-parents trios with a multi-allelic marker. Biometrical Journal 46 (5) : 606-611. ScholarBank@NUS Repository. https://doi.org/10.1002/bimj.200410057
Abstract: In case-parents trios design, the association between a multi-allelic candidate-gene and a disease can be detected by using maximum of score tests (max-score) when the mode of inheritance is known. We apply the maximum of the max-score statistics and the maximum of likelihood ratio statistics when the genetic model is unknown and examine their robust properties compared to max-score statistics. The simulation results demonstrate that the two maximum robust tests are more efficacious and robust across all genetic models compared with the three max-score tests. Moreover, in most situations, the maximum of the max-score tests seems to be more powerful than the maximum of the likelihood ratio tests.
Source Title: Biometrical Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/105339
ISSN: 03233847
DOI: 10.1002/bimj.200410057
Appears in Collections:Staff Publications

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