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https://doi.org/10.1016/j.biotechadv.2012.05.005
| Title: | Very small photoluminescent gold nanoparticles for multimodality biomedical imaging | Authors: | Lai, S.-F. Chien, C.-C. Chen, W.-C. Chen, H.-H. Chen, Y.-Y. Wang, C.-L. Hwu, Y. Yang, C.S. Chen, C.Y. Liang, K.S. Petibois, C. Tan, H.-R. Tok, E.-S. Margaritondo, G. |
Keywords: | Au nanoparticles Cellular uptake Cytotoxicity Photoluminescence Radiation synthesis Tumor development X-ray imaging |
Issue Date: | May-2013 | Citation: | Lai, S.-F., Chien, C.-C., Chen, W.-C., Chen, H.-H., Chen, Y.-Y., Wang, C.-L., Hwu, Y., Yang, C.S., Chen, C.Y., Liang, K.S., Petibois, C., Tan, H.-R., Tok, E.-S., Margaritondo, G. (2013-05). Very small photoluminescent gold nanoparticles for multimodality biomedical imaging. Biotechnology Advances 31 (3) : 362-368. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biotechadv.2012.05.005 | Abstract: | An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4. nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells. © 2012 Elsevier Inc. | Source Title: | Biotechnology Advances | URI: | http://scholarbank.nus.edu.sg/handle/10635/99035 | ISSN: | 07349750 | DOI: | 10.1016/j.biotechadv.2012.05.005 |
| Appears in Collections: | Staff Publications |
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