Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biotechadv.2012.05.005
Title: Very small photoluminescent gold nanoparticles for multimodality biomedical imaging
Authors: Lai, S.-F.
Chien, C.-C.
Chen, W.-C.
Chen, H.-H.
Chen, Y.-Y.
Wang, C.-L.
Hwu, Y.
Yang, C.S.
Chen, C.Y.
Liang, K.S.
Petibois, C.
Tan, H.-R.
Tok, E.-S. 
Margaritondo, G.
Keywords: Au nanoparticles
Cellular uptake
Cytotoxicity
Photoluminescence
Radiation synthesis
Tumor development
X-ray imaging
Issue Date: May-2013
Citation: Lai, S.-F., Chien, C.-C., Chen, W.-C., Chen, H.-H., Chen, Y.-Y., Wang, C.-L., Hwu, Y., Yang, C.S., Chen, C.Y., Liang, K.S., Petibois, C., Tan, H.-R., Tok, E.-S., Margaritondo, G. (2013-05). Very small photoluminescent gold nanoparticles for multimodality biomedical imaging. Biotechnology Advances 31 (3) : 362-368. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biotechadv.2012.05.005
Abstract: An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4. nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells. © 2012 Elsevier Inc.
Source Title: Biotechnology Advances
URI: http://scholarbank.nus.edu.sg/handle/10635/99035
ISSN: 07349750
DOI: 10.1016/j.biotechadv.2012.05.005
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