Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors

Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol8006875

Title:	Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors
Authors:	Srinivasan, R. Lay, P.T. Wu, H. Yao, S.Q.
Issue Date:	5-Jun-2008
Citation:	Srinivasan, R., Lay, P.T., Wu, H., Yao, S.Q. (2008-06-05). Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors. Organic Letters 10 (11) : 2295-2298. ScholarBank@NUS Repository. https://doi.org/10.1021/ol8006875
Abstract:	(Chemical Equation Presented) A highly efficient solid-phase strategy for assembly of small molecule inhibitors against protein tyrosine phosphatase 1B (PTP1B) is described. The method is highlighted by its simplicity and product purity. A 70-member combinatorial library of analogues of a known PTP1B inhibitor has been synthesized, which upon direct in situ screening revealed a potent inhibitor (Ki = 7.0 μM) against PTP1B. © 2008 American Chemical Society.
Source Title:	Organic Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/94831
ISSN:	15237060
DOI:	10.1021/ol8006875
Appears in Collections:	Staff Publications

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