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Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol8006875
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dc.titleSolid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors
dc.contributor.authorSrinivasan, R.
dc.contributor.authorLay, P.T.
dc.contributor.authorWu, H.
dc.contributor.authorYao, S.Q.
dc.date.accessioned2014-10-16T08:40:35Z
dc.date.available2014-10-16T08:40:35Z
dc.date.issued2008-06-05
dc.identifier.citationSrinivasan, R., Lay, P.T., Wu, H., Yao, S.Q. (2008-06-05). Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors. Organic Letters 10 (11) : 2295-2298. ScholarBank@NUS Repository. https://doi.org/10.1021/ol8006875
dc.identifier.issn15237060
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/94831
dc.description.abstract(Chemical Equation Presented) A highly efficient solid-phase strategy for assembly of small molecule inhibitors against protein tyrosine phosphatase 1B (PTP1B) is described. The method is highlighted by its simplicity and product purity. A 70-member combinatorial library of analogues of a known PTP1B inhibitor has been synthesized, which upon direct in situ screening revealed a potent inhibitor (Ki = 7.0 μM) against PTP1B. © 2008 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/ol8006875
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1021/ol8006875
dc.description.sourcetitleOrganic Letters
dc.description.volume10
dc.description.issue11
dc.description.page2295-2298
dc.identifier.isiut000256281600052
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