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|Title:||Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors|
|Citation:||Srinivasan, R., Lay, P.T., Wu, H., Yao, S.Q. (2008-06-05). Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors. Organic Letters 10 (11) : 2295-2298. ScholarBank@NUS Repository. https://doi.org/10.1021/ol8006875|
|Abstract:||(Chemical Equation Presented) A highly efficient solid-phase strategy for assembly of small molecule inhibitors against protein tyrosine phosphatase 1B (PTP1B) is described. The method is highlighted by its simplicity and product purity. A 70-member combinatorial library of analogues of a known PTP1B inhibitor has been synthesized, which upon direct in situ screening revealed a potent inhibitor (Ki = 7.0 μM) against PTP1B. © 2008 American Chemical Society.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
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