Please use this identifier to cite or link to this item:
|Title:||Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors|
|Source:||Srinivasan, R., Lay, P.T., Wu, H., Yao, S.Q. (2008-06-05). Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors. Organic Letters 10 (11) : 2295-2298. ScholarBank@NUS Repository. https://doi.org/10.1021/ol8006875|
|Abstract:||(Chemical Equation Presented) A highly efficient solid-phase strategy for assembly of small molecule inhibitors against protein tyrosine phosphatase 1B (PTP1B) is described. The method is highlighted by its simplicity and product purity. A 70-member combinatorial library of analogues of a known PTP1B inhibitor has been synthesized, which upon direct in situ screening revealed a potent inhibitor (Ki = 7.0 μM) against PTP1B. © 2008 American Chemical Society.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 16, 2018
WEB OF SCIENCETM
checked on Jan 2, 2018
checked on Jan 20, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.