Catalytic asymmetric bromoetherification and desymmetrization of olefinic 1,3-diols with C2-symmetric sulfides

Please use this identifier to cite or link to this item: https://doi.org/10.1021/ja5029155

Title:	Catalytic asymmetric bromoetherification and desymmetrization of olefinic 1,3-diols with C2-symmetric sulfides
Authors:	Ke, Z. Tan, C.K. Chen, F. Yeung, Y.-Y.
Issue Date:	16-Apr-2014
Citation:	Ke, Z., Tan, C.K., Chen, F., Yeung, Y.-Y. (2014-04-16). Catalytic asymmetric bromoetherification and desymmetrization of olefinic 1,3-diols with C2-symmetric sulfides. Journal of the American Chemical Society 136 (15) : 5627-5630. ScholarBank@NUS Repository. https://doi.org/10.1021/ja5029155
Abstract:	An enantioselective and highly diastereoselective bromoetherification and desymmetrization of olefinic 1,3-diols has been developed using a C 2-symmetric cyclic sulfide catalyst. This methodology has been successfully applied to the synthesis of the key intermediate of an orally active antifungal drug posaconazole (Noxafil). © 2014 American Chemical Society.
Source Title:	Journal of the American Chemical Society
URI:	http://scholarbank.nus.edu.sg/handle/10635/93236
ISSN:	15205126
DOI:	10.1021/ja5029155
Appears in Collections:	Staff Publications

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