Please use this identifier to cite or link to this item: https://doi.org/10.1021/ja5029155
Title: Catalytic asymmetric bromoetherification and desymmetrization of olefinic 1,3-diols with C2-symmetric sulfides
Authors: Ke, Z.
Tan, C.K.
Chen, F.
Yeung, Y.-Y. 
Issue Date: 16-Apr-2014
Citation: Ke, Z., Tan, C.K., Chen, F., Yeung, Y.-Y. (2014-04-16). Catalytic asymmetric bromoetherification and desymmetrization of olefinic 1,3-diols with C2-symmetric sulfides. Journal of the American Chemical Society 136 (15) : 5627-5630. ScholarBank@NUS Repository. https://doi.org/10.1021/ja5029155
Abstract: An enantioselective and highly diastereoselective bromoetherification and desymmetrization of olefinic 1,3-diols has been developed using a C 2-symmetric cyclic sulfide catalyst. This methodology has been successfully applied to the synthesis of the key intermediate of an orally active antifungal drug posaconazole (Noxafil). © 2014 American Chemical Society.
Source Title: Journal of the American Chemical Society
URI: http://scholarbank.nus.edu.sg/handle/10635/93236
ISSN: 15205126
DOI: 10.1021/ja5029155
Appears in Collections:Staff Publications

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