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Title: Liquid-crystal based optical sensors for simultaneous detection of multiple glycine oligomers with micromolar concentrations
Authors: Bi, X. 
Huang, S. 
Hartono, D. 
Yang, K.-L. 
Keywords: Ellipsometry
Glycine oligomers
Liquid crystal
Optical detection
Self-assembled monolayers
Issue Date: 15-Nov-2007
Citation: Bi, X., Huang, S., Hartono, D., Yang, K.-L. (2007-11-15). Liquid-crystal based optical sensors for simultaneous detection of multiple glycine oligomers with micromolar concentrations. Sensors and Actuators, B: Chemical 127 (2) : 406-413. ScholarBank@NUS Repository.
Abstract: This paper reports a novel liquid-crystal based method for the optical detection of multiple glycine oligomers simultaneously. The detection principle is based on the disruption of the orientations of a nematic liquid crystal 4-cyano-4′-pentylbiphenyl (5CB) supported on a surface patterned with multiple glycine oligomers. When glycine oligomers with different molecular lengths are immobilized on aldehyde-decorated surfaces under optimized conditions, they form monolayers with different thicknesses corresponding to their molecular lengths. As a result, the orientations of 5CB supported on the surfaces are disturbed when the thickness exceeds 0.5 ± 0.1 nm. Because liquid crystals are birefringent materials, the disruption of their orientations can cause optical signals visible to the naked eye. This liquid-crystal based detection scheme for glycine oligomers is able to detect 10 μM of triglycine, tetraglycine and pentaglycine, 100 μM of diglycine, and 1 mM of glycine with a sample size as little as 2 μL. It also provides a good spatial resolution over a large area and is sufficiently simple. © 2007 Elsevier B.V. All rights reserved.
Source Title: Sensors and Actuators, B: Chemical
ISSN: 09254005
DOI: 10.1016/j.snb.2007.04.040
Appears in Collections:Staff Publications

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