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https://doi.org/10.1016/j.snb.2007.04.040
Title: | Liquid-crystal based optical sensors for simultaneous detection of multiple glycine oligomers with micromolar concentrations | Authors: | Bi, X. Huang, S. Hartono, D. Yang, K.-L. |
Keywords: | Ellipsometry Glycine oligomers Liquid crystal Optical detection Self-assembled monolayers |
Issue Date: | 15-Nov-2007 | Citation: | Bi, X., Huang, S., Hartono, D., Yang, K.-L. (2007-11-15). Liquid-crystal based optical sensors for simultaneous detection of multiple glycine oligomers with micromolar concentrations. Sensors and Actuators, B: Chemical 127 (2) : 406-413. ScholarBank@NUS Repository. https://doi.org/10.1016/j.snb.2007.04.040 | Abstract: | This paper reports a novel liquid-crystal based method for the optical detection of multiple glycine oligomers simultaneously. The detection principle is based on the disruption of the orientations of a nematic liquid crystal 4-cyano-4′-pentylbiphenyl (5CB) supported on a surface patterned with multiple glycine oligomers. When glycine oligomers with different molecular lengths are immobilized on aldehyde-decorated surfaces under optimized conditions, they form monolayers with different thicknesses corresponding to their molecular lengths. As a result, the orientations of 5CB supported on the surfaces are disturbed when the thickness exceeds 0.5 ± 0.1 nm. Because liquid crystals are birefringent materials, the disruption of their orientations can cause optical signals visible to the naked eye. This liquid-crystal based detection scheme for glycine oligomers is able to detect 10 μM of triglycine, tetraglycine and pentaglycine, 100 μM of diglycine, and 1 mM of glycine with a sample size as little as 2 μL. It also provides a good spatial resolution over a large area and is sufficiently simple. © 2007 Elsevier B.V. All rights reserved. | Source Title: | Sensors and Actuators, B: Chemical | URI: | http://scholarbank.nus.edu.sg/handle/10635/89340 | ISSN: | 09254005 | DOI: | 10.1016/j.snb.2007.04.040 |
Appears in Collections: | Staff Publications |
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