Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.snb.2007.04.040
DC FieldValue
dc.titleLiquid-crystal based optical sensors for simultaneous detection of multiple glycine oligomers with micromolar concentrations
dc.contributor.authorBi, X.
dc.contributor.authorHuang, S.
dc.contributor.authorHartono, D.
dc.contributor.authorYang, K.-L.
dc.date.accessioned2014-10-09T06:52:38Z
dc.date.available2014-10-09T06:52:38Z
dc.date.issued2007-11-15
dc.identifier.citationBi, X., Huang, S., Hartono, D., Yang, K.-L. (2007-11-15). Liquid-crystal based optical sensors for simultaneous detection of multiple glycine oligomers with micromolar concentrations. Sensors and Actuators, B: Chemical 127 (2) : 406-413. ScholarBank@NUS Repository. https://doi.org/10.1016/j.snb.2007.04.040
dc.identifier.issn09254005
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/89340
dc.description.abstractThis paper reports a novel liquid-crystal based method for the optical detection of multiple glycine oligomers simultaneously. The detection principle is based on the disruption of the orientations of a nematic liquid crystal 4-cyano-4′-pentylbiphenyl (5CB) supported on a surface patterned with multiple glycine oligomers. When glycine oligomers with different molecular lengths are immobilized on aldehyde-decorated surfaces under optimized conditions, they form monolayers with different thicknesses corresponding to their molecular lengths. As a result, the orientations of 5CB supported on the surfaces are disturbed when the thickness exceeds 0.5 ± 0.1 nm. Because liquid crystals are birefringent materials, the disruption of their orientations can cause optical signals visible to the naked eye. This liquid-crystal based detection scheme for glycine oligomers is able to detect 10 μM of triglycine, tetraglycine and pentaglycine, 100 μM of diglycine, and 1 mM of glycine with a sample size as little as 2 μL. It also provides a good spatial resolution over a large area and is sufficiently simple. © 2007 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.snb.2007.04.040
dc.sourceScopus
dc.subjectEllipsometry
dc.subjectGlycine oligomers
dc.subjectLiquid crystal
dc.subjectOptical detection
dc.subjectSelf-assembled monolayers
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.snb.2007.04.040
dc.description.sourcetitleSensors and Actuators, B: Chemical
dc.description.volume127
dc.description.issue2
dc.description.page406-413
dc.description.codenSABCE
dc.identifier.isiut000251228600015
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