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Title: Cisplatin-loaded Au-Au2S nanoparticles for potential cancer therapy: Cytotoxicity, in vitro carcinogenicity, and cellular uptake
Authors: Ren, L.
Huang, X.-L.
Zhang, B.
Sun, L.-P.
Zhang, Q.-Q.
Tan, M.-C. 
Chow, G.-M. 
Keywords: Au-Au2S nanoparticles
Cellular uptake
Drug delivery
In vitro carcinogenicity
Near-IR sensitive
Issue Date: 1-Jun-2008
Citation: Ren, L., Huang, X.-L., Zhang, B., Sun, L.-P., Zhang, Q.-Q., Tan, M.-C., Chow, G.-M. (2008-06-01). Cisplatin-loaded Au-Au2S nanoparticles for potential cancer therapy: Cytotoxicity, in vitro carcinogenicity, and cellular uptake. Journal of Biomedical Materials Research - Part A 85 (3) : 787-796. ScholarBank@NUS Repository.
Abstract: Cisplatin is one of the most effective cytotoxic agents against cancers. Its usage, however, is limited because of severe resistance and systemic toxicity. A formulation of cisplatin-loaded Au-Au2S nanoparticles (NPs) with near-IR (NIR) sensitivity is reported to partly overcome this limitation in this paper. NIR sensitive Au-Au2S NPs were successfully synthesized by the reduction of tetrachloroauric acid (HAuCl4) using sodium sulfide (Na2S), and cisplatin was loaded onto Au-Au 2S NPs via a MUA (11-mercaptoundecanoic acid) layer. To further investigate the biological safety of cisplatin-loaded Au-Au2S NPs, three different cell lines were used to investigate the acute cytotoxicity and the long-term potential carcinogenicity in vitro. Cisplatin-loaded Au-Au 2S NPs were also tested for limited hemocompatibility in vitro. Our in vitro short and long-term data provided preliminary evidence suggesting that cisplatin-loaded Au-Au2S NPs with NIR sensitivity are nontoxic below the maximum recommended dosage. © 2007 Wiley Periodicals, Inc.
Source Title: Journal of Biomedical Materials Research - Part A
ISSN: 15493296
DOI: 10.1002/jbm.a.31608
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