Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.a.31608
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dc.titleCisplatin-loaded Au-Au2S nanoparticles for potential cancer therapy: Cytotoxicity, in vitro carcinogenicity, and cellular uptake
dc.contributor.authorRen, L.
dc.contributor.authorHuang, X.-L.
dc.contributor.authorZhang, B.
dc.contributor.authorSun, L.-P.
dc.contributor.authorZhang, Q.-Q.
dc.contributor.authorTan, M.-C.
dc.contributor.authorChow, G.-M.
dc.date.accessioned2014-10-07T09:48:05Z
dc.date.available2014-10-07T09:48:05Z
dc.date.issued2008-06-01
dc.identifier.citationRen, L., Huang, X.-L., Zhang, B., Sun, L.-P., Zhang, Q.-Q., Tan, M.-C., Chow, G.-M. (2008-06-01). Cisplatin-loaded Au-Au2S nanoparticles for potential cancer therapy: Cytotoxicity, in vitro carcinogenicity, and cellular uptake. Journal of Biomedical Materials Research - Part A 85 (3) : 787-796. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.a.31608
dc.identifier.issn15493296
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/86215
dc.description.abstractCisplatin is one of the most effective cytotoxic agents against cancers. Its usage, however, is limited because of severe resistance and systemic toxicity. A formulation of cisplatin-loaded Au-Au2S nanoparticles (NPs) with near-IR (NIR) sensitivity is reported to partly overcome this limitation in this paper. NIR sensitive Au-Au2S NPs were successfully synthesized by the reduction of tetrachloroauric acid (HAuCl4) using sodium sulfide (Na2S), and cisplatin was loaded onto Au-Au 2S NPs via a MUA (11-mercaptoundecanoic acid) layer. To further investigate the biological safety of cisplatin-loaded Au-Au2S NPs, three different cell lines were used to investigate the acute cytotoxicity and the long-term potential carcinogenicity in vitro. Cisplatin-loaded Au-Au 2S NPs were also tested for limited hemocompatibility in vitro. Our in vitro short and long-term data provided preliminary evidence suggesting that cisplatin-loaded Au-Au2S NPs with NIR sensitivity are nontoxic below the maximum recommended dosage. © 2007 Wiley Periodicals, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jbm.a.31608
dc.sourceScopus
dc.subjectAu-Au2S nanoparticles
dc.subjectCellular uptake
dc.subjectCisplatin
dc.subjectCytotoxicity
dc.subjectDrug delivery
dc.subjectIn vitro carcinogenicity
dc.subjectNear-IR sensitive
dc.typeArticle
dc.contributor.departmentMATERIALS SCIENCE AND ENGINEERING
dc.description.doi10.1002/jbm.a.31608
dc.description.sourcetitleJournal of Biomedical Materials Research - Part A
dc.description.volume85
dc.description.issue3
dc.description.page787-796
dc.description.codenJBMRC
dc.identifier.isiut000255530500026
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