Please use this identifier to cite or link to this item:
Title: Cisplatin-loaded Au-Au2S nanoparticles for potential cancer therapy: Cytotoxicity, in vitro carcinogenicity, and cellular uptake
Authors: Ren, L.
Huang, X.-L.
Zhang, B.
Sun, L.-P.
Zhang, Q.-Q.
Tan, M.-C. 
Chow, G.-M. 
Keywords: Au-Au2S nanoparticles
Cellular uptake
Drug delivery
In vitro carcinogenicity
Near-IR sensitive
Issue Date: 1-Jun-2008
Source: Ren, L., Huang, X.-L., Zhang, B., Sun, L.-P., Zhang, Q.-Q., Tan, M.-C., Chow, G.-M. (2008-06-01). Cisplatin-loaded Au-Au2S nanoparticles for potential cancer therapy: Cytotoxicity, in vitro carcinogenicity, and cellular uptake. Journal of Biomedical Materials Research - Part A 85 (3) : 787-796. ScholarBank@NUS Repository.
Abstract: Cisplatin is one of the most effective cytotoxic agents against cancers. Its usage, however, is limited because of severe resistance and systemic toxicity. A formulation of cisplatin-loaded Au-Au2S nanoparticles (NPs) with near-IR (NIR) sensitivity is reported to partly overcome this limitation in this paper. NIR sensitive Au-Au2S NPs were successfully synthesized by the reduction of tetrachloroauric acid (HAuCl4) using sodium sulfide (Na2S), and cisplatin was loaded onto Au-Au 2S NPs via a MUA (11-mercaptoundecanoic acid) layer. To further investigate the biological safety of cisplatin-loaded Au-Au2S NPs, three different cell lines were used to investigate the acute cytotoxicity and the long-term potential carcinogenicity in vitro. Cisplatin-loaded Au-Au 2S NPs were also tested for limited hemocompatibility in vitro. Our in vitro short and long-term data provided preliminary evidence suggesting that cisplatin-loaded Au-Au2S NPs with NIR sensitivity are nontoxic below the maximum recommended dosage. © 2007 Wiley Periodicals, Inc.
Source Title: Journal of Biomedical Materials Research - Part A
ISSN: 15493296
DOI: 10.1002/jbm.a.31608
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Feb 27, 2018


checked on Feb 19, 2018

Page view(s)

checked on Mar 12, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.