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Title: Dissipative particle dynamics simulation of field-dependent DNA mobility in nanoslits
Authors: Yan, K.
Chen, Y.-Z. 
Han, J.
Liu, G.-R. 
Wang, J.-S. 
Hadjiconstantinou, N.G.
Keywords: Computer simulation
Dissipative particle dynamics (DPD) method
Field-dependent mobility
Nanofluidic device
Issue Date: Jan-2012
Citation: Yan, K., Chen, Y.-Z., Han, J., Liu, G.-R., Wang, J.-S., Hadjiconstantinou, N.G. (2012-01). Dissipative particle dynamics simulation of field-dependent DNA mobility in nanoslits. Microfluidics and Nanofluidics 12 (1-4) : 157-163. ScholarBank@NUS Repository.
Abstract: The dynamics of DNA molecules in highly confined nanoslits under varying electric fields are studied using dissipative particle dynamics method, and our results show that manipulation of the electrical field can strongly influence DNA mobility. The mobility of DNA μ scales with electric field E as μ = μ H - k 1e-E/E e. And the data points for different DNA lengths finally approach each other in strong fields, which suggest that the sensitivity to chain length is almost lost. To explain the unusual field-dependent phenomena, we analyze the time evolution of DNA configurations under different fields. For strong driving potentials when the system is dominated by the electric driving force, the DNA chains are more likely to hold coiled configurations. For weak driving potential when the random diffusion forces dominate, we see frequent dynamic transitions between stretched and coiled configuration, which may increase the drag resistance, therefore reduce the mobility. © 2011 Springer-Verlag.
Source Title: Microfluidics and Nanofluidics
ISSN: 16134982
DOI: 10.1007/s10404-011-0859-5
Appears in Collections:Staff Publications

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