Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10404-011-0859-5
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dc.titleDissipative particle dynamics simulation of field-dependent DNA mobility in nanoslits
dc.contributor.authorYan, K.
dc.contributor.authorChen, Y.-Z.
dc.contributor.authorHan, J.
dc.contributor.authorLiu, G.-R.
dc.contributor.authorWang, J.-S.
dc.contributor.authorHadjiconstantinou, N.G.
dc.date.accessioned2014-10-07T09:03:00Z
dc.date.available2014-10-07T09:03:00Z
dc.date.issued2012-01
dc.identifier.citationYan, K., Chen, Y.-Z., Han, J., Liu, G.-R., Wang, J.-S., Hadjiconstantinou, N.G. (2012-01). Dissipative particle dynamics simulation of field-dependent DNA mobility in nanoslits. Microfluidics and Nanofluidics 12 (1-4) : 157-163. ScholarBank@NUS Repository. https://doi.org/10.1007/s10404-011-0859-5
dc.identifier.issn16134982
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/85015
dc.description.abstractThe dynamics of DNA molecules in highly confined nanoslits under varying electric fields are studied using dissipative particle dynamics method, and our results show that manipulation of the electrical field can strongly influence DNA mobility. The mobility of DNA μ scales with electric field E as μ = μ H - k 1e-E/E e. And the data points for different DNA lengths finally approach each other in strong fields, which suggest that the sensitivity to chain length is almost lost. To explain the unusual field-dependent phenomena, we analyze the time evolution of DNA configurations under different fields. For strong driving potentials when the system is dominated by the electric driving force, the DNA chains are more likely to hold coiled configurations. For weak driving potential when the random diffusion forces dominate, we see frequent dynamic transitions between stretched and coiled configuration, which may increase the drag resistance, therefore reduce the mobility. © 2011 Springer-Verlag.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s10404-011-0859-5
dc.sourceScopus
dc.subjectComputer simulation
dc.subjectDissipative particle dynamics (DPD) method
dc.subjectField-dependent mobility
dc.subjectNanofluidic device
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.contributor.departmentMECHANICAL ENGINEERING
dc.contributor.departmentPHYSICS
dc.description.doi10.1007/s10404-011-0859-5
dc.description.sourcetitleMicrofluidics and Nanofluidics
dc.description.volume12
dc.description.issue1-4
dc.description.page157-163
dc.identifier.isiut000299084300015
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